A Randomized Trial Comparing Monocryl(absorbable) vs. Nylon (traditional) Suture Closure in Carpal Tunnel Surgery

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Age: 18 years or older
Healthy Volunteers: No
Keywords: carpal tunnel, carpal tunnel surgery, carpal tunnel decompression surgery, carpal tunnel syndrome
Type: Procedure study
325 Participants
This research study hopes to determine if there is a significant difference in using two different types of sutures (stitches):
- subcuticular (under the skin) Monocryl (absorbable) vs
- traditional Nylon sutures (stitches)

These sutures will be used after open carpal tunnel decompression surgery. Both types of suture are commonly used in clinical practice. There is no objective data about which is “better”.
This study requires

If you agree to take part in this research study, you will not have to undergo any additional tests or visits outside of those involved for your carpal tunnel decompression surgery.

You will be randomized to one of two different closure options (closure with Monocryl sutures or Nylon sutures). The treatment you get will be chosen by chance, like flipping a coin. Neither you nor the study doctor will choose what treatment you get. You will have an equal chance of being given each treatment. You will not be told which treatment you are getting until your first post-operative appointment. However your study doctor will know. The Monocryl sutures are absorbable over 6-12 weeks, while the Nylon sutures are permanent. This means that the Nylon sutures must be removed in clinic.

You will then undergo surgery, and have your wound closed with the suture group you were assigned to. Post-operative dressings and care will be the same for both groups. Specific instructions will be in your discharge paperwork.

You will be seen for your regularly scheduled appointment at 10-14 days after surgery. At this appointment, if your wound was closed with Nylon sutures, these will be removed. You will be asked to fill out a short questionnaire, and the practitioner seeing you will also fill out a questionnaire about your scar.

You will next be seen at your regularly scheduled appointment 6 weeks after surgery. You will be asked to fill out a short questionnaire, and the practitioner seeing you will also fill out a questionnaire about your scar. This will conclude your study participation.

Who can participate

Inclusion criteria:

  • Patients at the University of California, Davis Health Center who are scheduled to undergo surgery for carpal tunnel release will be screened for eligibility for this study.
  • Patients who do not speak English will be included in this study, and will be provided with appropriate translators at all communication points.

Exclusion criteria:

  • Patients who are not able to follow up at the 2 and 6 week postoperative time points.
  • Patients who have known skin sensitivity to tape or absorbable suture.
  • Those who are unable to give informed consent, individuals who are not yet adults (18 years or older), pregnant women, and prisoners will be excluded from this study.
Benefits and risks of participating

We cannot promise any benefits to you as a result of taking part in this research study.


The study doctor will discuss the risks associated with taking part in this research study.
You will not be paid to take part in this research study.
Study duration and period
You will be in this research study until your final follow up appointment. At minimum six weeks after your surgery.
Recruitment period
From April 9, 2019
UC Davis Medical Center
2315 Stockton Boulevard
Sacramento, CA 95817
Research Topic
  • Carpal Tunnel Syndrome

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


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