|Age:||55 years or older|
|Keywords:||Age-related macular degeneration, AMD, vision loss|
The study team will make sure you qualify to take part in the study. Qualified participants will receive detailed information about the study. This may include a list of study-related tests and procedures.
Men and women aged 55 and older;
Clinical and Reading Center verification:
Best Corrected Visual Acuity of 20/25 or better; Cohort 1 – Early AMD: Medium drusen (>63µ and ≤125µ) OU Cohort 2 – RPD: At least one eye with RPD with no more than 1 large drusen (>125µ) in either eye. Cohort 3 – Controls: No medium or large drusen >63µ, no peripheral drusen, no RPD, or pigmentary
Previous ocular surgeries allowed include cataract surgery more than 3 months prior to enrollment in ARIS and peripheral laser, cryotherapy for peripheral tears;
Any evidence of CNV or GA in either eye;
Ocular disease other than AMD in either eye, in the Investigator’s opinion, which may confound assessment of the retina including
Previous retinal or other ocular surgical procedures, the effects of which may now or in the future complicate assessment of the progression of AMD in the Investigator’s opinion; a. These surgeries can be divided into those for 1) glaucoma: argon laser trabeculoplasty, trabeculectomy, and other penetrating glaucoma surgery involving valves, etc., 2) retinal diseases: laser photocoagulation (except to repair a peripheral retinal hole), cryosurgery (except any procedure to repair a peripheral retinal hole), intravitreal injections, vitrectomy 3) Refractive surgery: Lasik, peripheral radial keratotomy (PRK), KAMRATM (corneal inlay for correction of presbyopia), 4) corneal diseases: lamellar keratoplasty, penetrating keratoplasty (PKP), Descement Membrane Endothelial Keratoplasty (DMEK), Descemet Stripping Endothelial Keratoplasty (DSEK), DSEK-A (DSEK-automated), Ultra-thin DESK, Deep Anterior lamellar Keratoplasty (DALK), 5) pterygium surgery that affects or threatens the visual axis, Others) radiation for ocular tumor, repair of corneal or sclera laceration. b. Retinal laser treatments and cryosurgery for retinal tears is not an exclusion.
Any other ocular condition requiring long-term therapy or surgery during the study or any other retinal pathology that in the Investigator’s opinion will interfere with the interpretation of the macular AMD findings (e.g., CRVO);
Participants with confirmed glaucoma (visual field and/or disc/nerve fiber layer defects); a. Participants with a current IOP > 26, a history of the diagnosis of increased intraocular pressure, glaucoma, past or present use of medications to control intraocular pressure, or disc/nerve fiber layer defects suggestive of glaucoma can be eligible if the absence of a glaucomatous visual field defect can be documented by a normal Goldmann, Humphrey or Octopus perimetry test within six months prior to qualification.
Participant has photographically significant corneal or media opacities;
Participant has, in the opinion of the Investigator, any physical or mental condition that would increase the risk of participation in the study or may interfere with the study procedures, evaluations and outcome assessments;
Participant is medically unable to comply with study procedures or follow-up visits.
Participation in a research study involving treatment for AMD.
Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.