A Study of Antibodies in the Blood in Patients With Auto-Immune Neurological Diseases

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Study coordinator
Name - Molly Lindsay, MS, CCRP
Email - melindsay@ucdavis.edu
Phone - (916) 734-6312

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"Do you have multiple sclerosis or another autoimmune disease? We are studying specific antibodies that may have an impact on your health."
Age: 18 years or older
Healthy Volunteers: No
Keywords: multiple sclerosis, autoimmune disease, neurological disease
Type: Other study
240 Participants
This is a research study of the immune system. Under normal conditions, our immune system protects us against infections and tumors. The immune system recognizes when an infecting organism or tumor is foreign to your body and attacks it. One way the immune system attacks a foreign target is by making proteins called antibodies that bind to the target. Sometimes, for reasons we don't understand, the immune system identifies part of our own body as being foreign and attacks it. We will test your blood to see if your immune system is making antibodies against components of your nerves and muscle, and will also test for the antioxidant molecule frataxin. We want to learn if these antibodies contribute to the development or worsening of illnesses of the nervous system.
This study requires

If you decide to take part in this study, you will be asked to:

-Blood draw (venipuncture): A blood sample will be drawn by inserting a needle into a vein in your arm. The sample will be approximately 1 tablespoon. To minimize your discomfort, blood samples will be taken at the time that other blood is drawn unless there are no other laboratory tests ordered at that visit.You may be asked, however, to give blood up to 8 more times in the future to see if the level of antibodies change over time. Any additional blood draws would be performed at regularly scheduled clinic visits. There would be at least 3 months between blood draw over a period of up to 3 years if requested by the physician.

-Cheek Swab: We will also swish a swab around your mouth to collect mouth (buccal) cells. This takes about one minute, and is painless. We will swab your mouth every time we draw blood for this study.

Who can participate

Inclusion criteria:

  • 18 years or older
  • Diagnosis of multiple sclerosis, myasthenia gravis, or other autoimmune or inflammatory neurological disease

Exclusion criteria:

  • inability to give informed consent
Benefits and risks of participating

There will be no direct benefit to you from participating in this study. However, this study will help doctors learn more about ways changes in the immune system may lead to disease of the nervous system. We hope this information will help treat future patients with conditions like yours.


Blood drawing (venipuncture) risks: Drawing blood may cause temporary discomfort from the needle stick, bruising, and infection.

Buccal swab risks: There are no known health risks from a cheek swab.

Unknown Risks: The researchers will let you know if they learn anything that might make you change your mind about participating in the study.

Privacy Risks: There may also be risks to your privacy. The Researchers will store study records and other information about you in a secure location and will grant access only to those with a need to know.

For more information about risks and side effects, ask the Researcher.
You will not be paid for taking part in this study.
Study duration and period
You will be asked to participate for a total of about 30 minutes – enough time for one blood draw and one cheek swab. You may be asked to come back to have up to 8 more blood draws.
Recruitment period
From June 30, 2011
UC Davis Midtown Neurology Clinic
3160 Folsom Boulevard
Sacramento, CA 95816
Molly Lindsay, MS, CCRP
Research Topic
  • Multiple Sclerosis
  • Myasthenia Gravis
  • Transverse Myelitis

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


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