A Study of the Effect of Mango Intake (Mangifera Indica L.) on Blood Pressure and Blood Glucose in Post-Menopausal Women

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"Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!"
Age: 50 to 70 years old
Gender:
Female
Healthy Volunteers: Yes
Keywords: blood pressure, blood glucose, post-menopause, women, post-menopausal women
Type: Other study
Target:
10 Participants
Investigator:
Description
We hope to learn if the consumption of mango can be beneficial to your health. Previous studies have found that mango has a high polyphenol content. This may have the potential to benefit cardiovascular health. In addition we hope to learn how mango might benefit your blood glucose.
This study requires

If you decide to volunteer, you will be asked to participate in a screening visit. This will be held at the Ragle Human Nutrition Research Center (1283 Academic Surge) on UC Davis campus.

We will start the screening session by obtaining your consent to participate in the study. We will then measure your height, weight, waist circumference, blood pressure and heart rate 3 times, 5 minutes apart, after a 15-minute rest, and have you fill out a questionnaire on your health, diet, and medication and supplement use.

You will then be asked to donate a fasting blood sample (30 mL ~ 2 tablespoons). A retest blood sample may be requested by the study physician or if a blood sample is not able to be processed for analysis. If a retest is requested, you will be asked whether or not you are willing to submit another fasting blood sample, and you will be appropriately compensated for your time, which will be the same amount as for a screening visit.

Who can participate

Inclusion criteria:

  • Postmenopausal female: 50-70 years
  • Women: lack of menses for at least one year and FSH 23-116.3 mlU/mL
  • Subject is willing and able to comply with the study protocols.
  • Subject is willing participate in all study procedures
  • BMI 25.0 - 40 kg/m2
  • Weight ≥ 110 pounds

Exclusion criteria:

  • BMI ≥ 40 kg/m2
  • Dislike or allergy for mango
  • Self-reported use of daily anticoagulation agents including aspirin, NSAIDs
  • Vegan, Vegetarians, food faddists or those consuming a non-traditional diet
  • Alcohol consumption > 3 drinks/week (i.e. 1 bottle of beer, 1 glass of wine, and 1 shot of hard liquor)
  • Fruit consumption ≥ 2 cups/day
  • Vegetable consumption ≥ 3 cups/day for females
  • Fatty Fish ≥ 3 times/week
  • Coffee/tea ≥ 3 cups/day
  • Dark chocolate ≥ 3 oz/day
  • Self-reported restriction of physical activity due to a chronic health condition
  • Self-reported chronic/routine high intensity exercise
  • Self-reported diabetes
  • Blood pressure ≥ 140/90 mm Hg
  • Self-reported renal or liver disease
  • Self-reported heart disease, which includes cardiovascular events and Stroke
  • Abnormal Liver, CBC or Chemistry panels (laboratory values outside the reference range) if determined to be clinically significant by the study physician.
  • Self-reported cancer within past 5 years
  • Self-reported malabsorption
Benefits and risks of participating
BENEFITS:

We cannot promise any benefits to you as a result of taking part in this research study.


RISKS:

The study doctor will discuss the risks associated with taking part in this research study.
Compensation
If you agree to take part in this research study, we will compensate you $245 for your time and effort. This will include $20 for the screening visit, $30 for each completed study day, and $15 for each blood draw.
Resources
Schedule
Study duration and period
You will be asked to participate in 3 study visits that are at least 48 hours apart. The study includes a screening visit and three study day visits at the Ragle Human Research Center on UC Davis campus. Each study day will last approximately 4 hours
Recruitment period
From July 29, 2019
Research Topic
Conditions:
  • Blood Pressure

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


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