A Study of the Effect of Probiotics on Gastrointestinal Function During Pregnancy

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Age: 18 and over
Healthy Volunteers: No
Keywords: nausea, vomiting, pregnancy, probiotics, GI, constipation
Type: Dietary Supplement study
100 Participants
The purpose as well as the aim of this project is to understand the effect of probiotics on gastrointestinal (GI) dysfunction such as nausea, vomiting, and constipation that are found during the first and second trimesters of pregnancy. Do probiotics have an effect on GI functional disorders? What intestinal microbes change with probiotic intake?
Who can participate

Inclusion Criteria:

  • First and second trimester healthy or low risk pregnant women who report gastrointestinal disorders such as nausea, vomiting, and constipation

Definition of healthy or low risk pregnant women:

  • Systolic blood pressure < 140 mmHg and diastolic blood pressure < 90 mmHg
  • Hemoglobin ≥ 10.0 g/dL
  • Have immunity against rubella (German measles)
  • HIV negative
  • Urine test shows no sign of kidney or urinary tract infection
  • 27 weeks 6 days gestation or less with confirmed fetal heart beat
  • Pregnant women age 18 and older

Exclusion Criteria:

  • High risk pregnant women who have existing health conditions such as high blood pressure, Type 1 diabetes, HIV positive, or are infected with Hepatitis B, Syphilis, or other sexually transmitted diseases
  • Pregnant women who have multiple gestations or a history of recurrent miscarriages (more than two consecutive miscarriages)
  • Had prior bariatric surgery
  • Conceived through IVF program
  • Pregnant women who have had severe weight loss (more than 5 pounds) during pregnancy. [Note: Mild weight loss (2-3 pounds) due to nausea, vomiting, or loss of appetite is considered normal.]

  • Medical history of irritable bowel syndrome or other non-pregnancy related GI dysfunction/disorder

UC Davis Heath
4860 Y Street
Suite 2500
Sacramento, CA 95817
Research Topic
  • Pregnancy Early
  • Nausea Gravidarum
  • Vomiting of Pregnancy

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