A Study of the Effects of Sweet Cherry Juice on Metabolism (converting food to energy) and Heart Health

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Have questions? Please contact the study coordinator Ellen Bonnel at elbonnel@UCDAVIS.EDU or call (530) 752-4184
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  1. *1. How old are you?
  2. *2. Are you Male or Female?
  3. *3. What is your height? (in inches)
  4. *4. What is your weight? (in lbs)
  5. *5. Have you ever been told you have high blood pressure or are hypertensive?
  6. *6. Are you taking any perscription medications
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"Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!"
Age: 20 to 65 years old
Healthy Volunteers: Yes
Keywords: cherry juice, heart health, metabolism, sweet cherry juice
Type: Dietary Supplement study
30 Participants
This research study will test whether regular consumption of cherry juice improves cardiovascular (heart) and metabolic (converting food to energy) health.

This study will involve:
- daily consumption of study beverages,
- tracking study beverage and food consumption in a food diary,
- completion of 9 at-home dietary records,
- one screening visit and 6 study visits.

Here are some reasons you may not want to participate in this research:
- You may find frequent test visits at the research center inconvenient and time consuming.

- You may find it tedious to:
-- drink study beverages,
-- limit consumption of certain foods and beverages,
-- complete dietary records and questionnaires.

- You may find the following procedures uncomfortable:
-- blood draws,
-- the PAT procedure,
-- continuous blood pressure monitoring (CNAP)
-- MindWare electrode placement.
This study requires

If you participate in this 12 week study, you will be receive two controlled beverages, a sweet cherry juice and a placebo. A placebo is a substance that has no active ingredients. You will come to the WHNRC once a week to pick-up your study beverages and review food records. Following baseline week 1, you will begin consuming the first beverage and continue to do so 2 times a day for 6 weeks. For the last 6 weeks of the study, you will consume the opposite beverage of what you’ve consumed for the first 6 weeks.

You will be given each treatment. The treatment order that you get will be chosen by chance, like flipping a coin. Neither you nor the researchers will choose what treatment you get first.

This study involves consuming a controlled beverage for 12 weeks. During this period, you will consume the provided beverage twice a day. After the screening visit, 3 days before and during the 12 week study, you will stop supplement intake or limit intake to one approved multi-vitamin and mineral supplement per day. You will stop consuming fresh, frozen, dried or juiced cherries for the duration of the study (not including the study beverages).

During the 3 days before each test visit day, you will be asked to limit the intake of polyphenol-containing foods. This includes: - fruits, - vegetables, - whole grains, - nuts, - seeds, - olive oil, - herbs, - spices, - condiments, - cocoa products, - coffee, - tea, - red wine, - omega-3 containing foods, including - fatty and non-fatty fish, - flaxseed oil, - walnut oil, - canola oil

Intake of other vegetable oils will also be limited during the 3 days before each test visit day. You must be willing to stop consuming alcohol-containing beverages for 3 days before each test visit day.

Who can participate

Inclusion criteria:

  • Men aged 20 - 65 years
  • Post-menopausal women aged 45 - 65 years
  • Body Mass Index ≥25 and <40 kg/m2
  • Systolic blood pressure >120 and <140 mmHg or diastolic blood pressure >80 and <90 mmHg

Exclusion criteria:

  • Diagnosed metabolic disorder
  • Diabetes mellitus
  • Thyroid disease
  • Cardiovascular disease
  • Poly-cystic ovary syndrome
  • Vasoconstrictive diseases (e.g. Raynaud's phenomenon or Raynaud's disease)
  • Digestive disorder (e.g. Crohn's, irritable bowel syndrome, colitis)
  • History of gastrointestinal surgery affecting digestion and/or absorption
  • Use of medications for hypertension, hyperlipidemia, glycemic control, or weight loss
  • Use of medications such as steroids, statins, or non-steroidal anti-inflammatory agents
  • Routine use of over-the-counter medications
  • Weight change >5% in the past 6 months
  • Performing exercise greater than 60 minutes/day
  • Presence of a pacemaker or other internal electronic device controlling rhythm or pacing of heart excludes participant from MindWare procedure
  • Presence of atrial fibrillation or other arrhythmia excludes participant from MindWare procedure
Benefits and risks of participating

We cannot promise any benefits to you as a result of taking part in this research study.


The study doctor will discuss the risks associated with taking part in this research study.
We will pay you $400 for participating in this study. Payment will be provided at the end of the study in the form of a check or electronic funds transfer. If you choose to leave or we take you off the study before you complete the study, you will receive $50 for attending test day 1 and $50 for attending test day 2 during week 0. During week 6, you will receive $50 for attending test day 3 and $50 for attending test day 4 during. During the week 12, you will receive $100 for attending test day 5 and $100 for attending test day 6.
Study duration and period
You will be asked to come to the study site in Davis 17 times over the course of 14 weeks. The screening visit will last about 2 hours. Most of these visits will last about 30 minutes. The 6 test visits that are scheduled for research data collection may last from 4 to 8 hours.
Recruitment period
From April 4, 2019
Research Topic
  • Obesity
  • Metabolic Syndrome

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


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