|Age:||18 years or older|
|Keywords:||asthma, severe asthma, obesity|
|Type:||Drug study, Phase 1|
If you decide to take part in this study, you will take part in two study visits. You will be asked about your height and weight. The first time we will ask you some standard questions to make sure you are fit and able to breathe deeply. For the lung health measurements, you will be asked to blow forcefully into a hand held (small) instrument (an office spirometer) that measures the air you exhale. You will also be asked to have your blood drawn in two small tubes. You will fill out a brief questionnaire.
If you decide to volunteer, you will be one of 24 adult subjects who will participate. The study will take up to 1-hour of your time per study visit, and requires a total of 2 study visits over a 90 day period. In addition you will be asked to perform and record daily peak flow measurement (morning and night), which will take less than 5 minutes a day.
At each visit, a brief history and physical exam will be performed. If you qualify and agree to participate you will be randomly (coin toss) assigned to one of two groups: a group that takes the placebo, and a group that takes the Roflumilast. This is a blinded study, so neither you nor the investigators will know what you are taking until the study has been completed.
You will have 2 testing sessions when you undergo testing of your blood, breath, and sputum. The first session occurs before you start taking the pills.
Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.