A Study of the Experimental Medicine Ropivacaine for Pain Control After Kidney Transplant

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Age: 18 years or older
Healthy Volunteers: No
Keywords: pain control, renal transplant surgery, kidney transplant
Type: Drug study, Phase 4
200 Participants
This study is for patients scheduled to have kidney transplant surgery at the UC Davis Medical Center.

It will compare two different methods for controlling pain after kidney transplant surgery. These methods are called TAP blocks and are designed to numb the nerves around the area of surgery.

One method uses small implanted catheters to slowly give the anesthetic drug ropivacaine for two to three days after surgery. The other method uses a single injection of a long-acting anesthetic called liposomal bupivacaine. It lasts for two to three days after surgery.

The study is designed to compare the effectiveness of these two different methods of decreasing pain. In addition, the study will compare the costs of these two different methods.
This study requires

If you decide to take part in this study, you will be asked to allow the researchers to perform a TAP block. This is a pain reducing method designed to numb the nerves going to the muscles in the abdomen for pain control after your surgery.

You will be randomly assigned to a treatment based on chance, like a flip of a coin. Neither you nor the researcher chooses your assigned group. You will have an equal chance of being in either group. You will be informed of which study arm/group you are in after receiving your informed consent.

The anesthesiologist will perform the TAP block procedure. They will use either ropivicaine continuous infusion catheters or single dose liposomal bupivacaine. Using an ultrasound as a guide, the anesthesiologist will locate the space between the two abdominal muscles.

Once the location is found, the anesthesiologist will enter the skin with the needle and inject the local anesthetic. An Acute Pain Service anesthesiologist will follow your care from the beginning of the TAP block until your discharge. Prior to your discharge, you will be asked to complete a post-op survey for participation.

Who can participate

Inclusion criteria:

  • Patients ages 18 years or older
  • Renal Transplant Recipients

Exclusion criteria:

  • Patients less than 18 years of age
  • Pregnant Women
  • Prisoners
  • Opioid Tolerant Patients taking more than 30 mg/day of oral morphine equivalent analgesia
  • Patients on Systemic anti coagulation
  • Patients unable to provide consent
  • Hypersensitivity to amide-type local anesthetic or any component of the drug formula
Benefits and risks of participating

We cannot promise any benefits to you as a result of taking part in this research study.


The study doctor will discuss the risks associated with taking part in this research study.
You will not be paid to take part in this research study.
Study duration and period
You will be in the study until you are discharged from the hospital after your surgery.
Recruitment period
From Aug. 15, 2018
UC Davis Medical Center
2315 Stockton Boulevard
Sacramento, CA 95817
Research Topic
  • Transplant;Failure,Kidney
  • Pain, Postoperative

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


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