A Study of the Experimental Medicine Rucaparib for Recurrent Non-small Cell Lung Cancer

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"Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!"
Age: -1 years or older
Gender:
Any
Healthy Volunteers: No
Keywords: lung cancer, non-small cell lung cancer, cancer
Type: Drug study, Phase 2
Target:
40 Participants
Investigator:
Description
We are asking you to take part in this research study because you have non-small cell lung cancer. We are asking you to submit your tumor sample to test for specific genes and proteins. Based on the test results, you will be assigned to one of the treatment sub-studies.
This study requires

The study team will make sure you qualify to take part in the study. Qualified participants will receive detailed information about the study. This may include a list of study-related tests and procedures.

Who can participate

Patients must have pathologically proven non-small cell lung cancer (all histologic types) confirmed by tumor biopsy and/or fine-needle aspiration. Disease must be Stage IV as defined in Section 4.0, or recurrent. The primary diagnosis of non-small cell lung cancer should be established using the current WHO/IASLC-classification of Thoracic Malignancies. (13) All histologies, including mixed, are allowed.

Benefits and risks of participating
BENEFITS:

We cannot promise any benefits to you as a result of taking part in this research study.


RISKS:

The study doctor will discuss the risks associated with taking part in this research study.
Compensation
You will not be paid to take part in this research study.
Resources
Schedule
Study duration and period
If you decide to take part in this study, we will ask you to submit a tumor sample which will be tested for specific genes and proteins. Based on the test results, you will be assigned to one of the treatment sub-studies. Your study doctor will check your health status for this study every six months for up to three years. At the follow up visits you will have a physical exam, and scans. Your doctor may give you other tests or procedures if they think they are needed for the regular care of your disease.
Recruitment period
From Feb. 19, 2019
Location
UC Davis Comprehensive Cancer Center
4501 X Street
Sacramento, CA 95817
Research Topic
Conditions:
  • Deleterious BRCA1 Gene Mutation
  • Deleterious BRCA2 Gene Mutation
  • Loss of Heterozygosity
  • Lung Non-Small Cell Squamous Carcinoma
  • Recurrent Large Cell Lung Carcinoma
  • Recurrent Lung Adenocarcinoma
  • Recurrent Lung Non-Small Cell Carcinoma
  • Recurrent Non-Squamous Non-Small Cell Lung Carcinoma
  • Stage IV Lung Cancer AJCC v8
  • Stage IVA Lung Cancer AJCC v8