A Study of the Experimental PET/CT Radiotracer "18F-avb6-Binding-Peptide" After COVID-19 (Coronavirus) Infection

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For questions and more information about this study, please contact the team using the information below.
Study coordinator
Name - Julie Sutcliffe
Email - jlsutcliffe@ucdavis.edu
Phone - (916) 734-5536

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"Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!"
Age: 18 years and older
Gender:
Any
Healthy Volunteers: No
Keywords: COVID-19, coronavirus
Type: Other Study
Target:
10 Participants
Investigator:
Description
Researchers at UC Davis have developed a new drug to aid in the detection of lung damage. This drug is called a “radiotracer." It attaches to damaged cells and shines a light that can be seen using a special camera, called a “positron emission tomography” or “PET” scanner. We hope this new radiotracer will improve the ability to locate possible lung damage. This new radiotracer is called Fluorine-18 Alpha-V Beta-6 Binding Peptide.
This study requires

If you decide to take part, we will ask you to come into the Nuclear Medicine Department, UC Davis Medical Center, Sacramento.

If you are pregnant or are breast-feeding, you will not be able to take part in this study. All women will be required to have a pregnancy test the day of the scan prior to commencement of the study.

A Nuclear Medicine Technologist and a Study Physician will be with you during your scanning. We will first insert a small plastic needle, called an intravenous or “IV” catheter into a vein in your arm. A blood pressure cuff will be placed on the opposite arm. We will inject the radiotracer and let you rest quietly for about an hour. We will then position you on your back on the scanner table with cushions to make you comfortable.

The scanning will take approximately 30 minutes. Before the scanning, we will take a blood samples (less than 3 tablespoons ). We will also check your temperature and blood pressure. After the scan is over, your participation will be completed for that day. It is anticipated the visit will take up to 2 hours.

Approximately 3 months after your PET scan, we will ask you to come back to the clinic for your second scan and again 3 months later for your third scan. After these visits, your active participation will be complete. We will then check on your progress using your medical record for up to twelve months to see how you are doing with any testing or treatment you may receive.

Who can participate

Subject population and eligibility:

Volunteers of all ethnicities and sexes will be eligible for the study. Children under the age of 18 will not participate in this study. This is due to the higher risk associated with radiation in this age group. Pregnant women will not be allowed to participate in this due to potential radiation exposure to the unborn fetus. Prisoners will not be eligible for the study. The target number of subjects for this study is 10. Patient volunteers with a prior diagnosis of SARS CoV2 are included.

Inclusion Criteria:

  • Men and women age ≥ 18 yrs.;
  • Diagnosed with SARS CoV2;
  • 2 sequential COVID negative tests prior to each scan;
  • No previous lung disease prior to SARS CoV2 infection;
  • lung image (Xray or CT) during infectious/ diagnosis period (vi) will sign the IRB-approved consent form;
  • able to remain motionless for up to 30-60 minutes per scan.

Exclusion Criteria:

  • life expectancy <3 mo.;
  • women who are pregnant or breast-feeding;
  • patients who cannot undergo PET/CT scanning because of weight limits(>350lbs);
  • lack of availability for follow-up assessments;
  • re-infection with SARS CoV2 between scan sessions;
  • other active infectious respiratory illness
Benefits and risks of participating
BENEFITS:

We cannot promise any benefits to you as a result of taking part in this research study.


RISKS:

The study team will discuss the risks associated with taking part in this research study.
Compensation
You will not be paid to take part in this research study.
Resources
Schedule
Study duration and period
We expect that you will be in this research study for one day every three months for up to twelve months.
Recruitment period
From April 16, 2020
Location
UC Davis Medical Center
2315 Stockton Boulevard
Sacramento, CA 95817
Research Topic
Conditions:
  • COVID-19
  • coronavirus

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


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