"What are the effects of consuming sugar-sweetened beverages with meals people typically consume?"
18 to 40 years old
obesity, Type II Diabetes
It is not known whether consumption of excessive amounts of sugar can increase risk factors for cardiovascular disease or diabetes in the absence of increased food (caloric) intake and weight gain, nor whether the negative effects of sugar consumption are made worse when accompanied by weight gain. This study will investigate the effects of excess sugar when consumed with an energy-balanced diet that prevents weight gain, and the effects of excess sugar when consumed with a diet that can cause weight gain. The results will determine whether excess sugar consumption and excess caloric intake that lead to weight gain have independent and additive effects on risk factors for cardiovascular disease or diabetes, and will have the potential to influence dietary guidelines and public health policy.
This study requires
Approximately 33 study visits Please contact for details
Who can participate?
- BMI 22-28 kg/m2
- Self-reported stable body weight during the prior six months
- Fasting glucose >105 mg/dl
- Evidence of liver disorder [AST (Aspartate Aminotransferase) or ALT (Alanine Aminotransferase)] >200% upper limit of normal range)
- Evidence of kidney disorder (>2.0mg/dl creatinine)
- Evidence of thyroid disorder (out of normal range)
- Systolic blood pressure consistently over 140mm Hg (mercury) or diastolic blood pressure over 90mmHg
- Triglycerides > 200mg/dl
- LDL-C > 130mg/dl in combination with Chol:HDL > 4
- Hemoglobin < 8.5 g/dL
- Pregnant or lactating women
- Any other condition that, in the opinion of the investigators, would put the subject at risk
- Current, prior (within 12 months), or anticipated use of any hypolipidemic or anti-diabetic agents.
- Use of thyroid, anti-hypertensive, anti-depressant, weight loss medications or any other medication which, in the opinion of the investigator, may confound study results
- Use of tobacco
- Strenuous exerciser (>3.5 hours/week at a level more vigorous than walking)
- Surgery for weight loss
- Diet exclusions: Food allergies, special dietary restrictions, food allergies, routine consumption of less than 3 meals/day, routine ingestion of more than 2 sugar-sweetened beverages or 1 alcoholic beverage/day, unwillingness to consume any food on study menu
- Hydrogen concentration in breath sample following consumption of HFCS-beverage during screening >50ppm
- Veins that are assessed by the CCRC (Clinical Research Center) R.N.s as being unsuitable for long-term infusions and multiple blood draws from a catheter.
- Pre-existing claustrophobia or metal implants that preclude MRI