Due to the current situation related to the coronavirus (COVID-19), study teams may experience delays in responding to signups and scheduling patients on StudyPages.A study team member will respond to you as soon as possible. More coronavirus resources and updates from UC Davis Veterinary Medicine can be found here.

Assessing a Stem Cell Therapy for Inflammatory Brain Disease in Dogs
Logo Image
"Help us find a treatment for inflammatory brain disease in dogs using stem cells!"
Animal: Dogs
Age: None specified
Healthy Pets: No
Keywords: inflammatory brain disease, stem cell, stem cell therapy, dog, canine, brain, inflammatory central nervous system disease
Type: Other - Stem Cells
30 Participants
Background and purpose
Inflammatory central nervous system disease is a severe inflammatory disease in dogs, which can cause severe disease in the brain and spinal cord, causing dogs to become very sick. None of the current treatments are ideal, predictable and without possible complications. In recent years, stem cells have shown some promise as a potential treatment option for chronic inflammatory diseases, therefore, the purpose of this study is to assess the efficacy of stem cell therapy on dogs with inflammatory brain disease.
What happens in this study
  • Chest xrays and abdominal ultrasound at the initial visit;
  • Collection of blood and urine before the treatment and at the 4 and 8 week recheck visits;
  • MRI of the brain and/or spinal cord while under anesthesia and cerebrospinal fluid (CSF) analysis performed at the initial visit, and the 4 and 8 week recheck visits;
  • Administration of stem cells either:
  • Intravenously at the initial visit and potentially at the 4 and 8 week visits (Group A); or,
  • Intravenously and directly injected into the spinal fluid at the initial visit and potentially at the 4 week and 8 week visits (Group B).

NOTE: Your dog will hospitalized for 1-3 days after every stem cells administration.

Pet owner responsibilities

If you allow your dog to participate in this study, you will be responsible for keeping all scheduled appointments and covering any costs beyond the $2500 credit towards medical treatment of adverse events.

Participation requirements

We are looking for dogs diagnosed with inflammatory brain disease.

Benefits and risks of participating
Participation in this trial will hopefully change the quality of life of your dog. If this study will prove to be beneficial, it will have important clinical applications for other dogs with the same condition. Moreover, it is possible that if proven beneficial, this treatment can be introduced to human medicine for similar indications.
The study will cover the costs for the blood work, urinalysis, chest xray, abdominal ultrasound, hospitalization, MRI, CSF analysis, stem cell administration, and visit fees. Additionally, the study will also pay up to $2500 for medical treatment to cover any adverse events that occurred as a result of participating in the study.
PDF Docs
Study duration and period
We expect that participation in this clinical trial will last for 6 months. We will treat your dog with stem cells at least once, but potentially every 4 weeks for up to three treatments with three months of follow up, depending on how well your dog responds to the stem cell treatment. If your dog is not showing improvement in the symptoms, or worsens by the 4 or 8 week period after the initial treatment, two or three treatments may be performed.
Recruitment period
From March 8, 2018 to March 8, 2019
UC Davis Veterinary Medical Teaching Hospital
1 Garrod Drive
Small Animal Clinic - Neurology and Neurosurgery
Davis, CA 95616
Dr. Karen Vernau

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


Send SMS with Study Info:

SMS Sent!

Share Study Info via Email:

E-mail Preview