18 to 100 years old
cancer, biopsy, tumor
Procedure study, Phase 1
Blood tests Biopsies Medical information about the type of cancer, cancer drugs taken, and how your tumor responded to the cancer drugs
Patients who are being evaluated and or treated for cancer at the NIH Clinical Center or at participating sites.
Ability to understand and willingness to sign a written informed consent document indicating their willingness to have their tissue or biologic fluid specimens used for research as outlined in this protocol.
Age greater than 18 years
Patients with invasive fungal infections
Patients with active and/or uncontrolled infections or who are still recovering from an infection:
Actively febrile patients with uncertain etiology of febrile episode
All antibiotics should be completed at least 1 week (7 days) prior to collection
No recurrence of fever or other symptoms related to infection for at least 1 week (7 days) following completion of antibiotics
Patients with Human Immunodeficiency Virus (HIV), active or chronic hepatitis (i.e., quantifiable HBV-DNA and/or positive HbsAg, quantifiable HCV-RNA) or known history of HCV or HBV without documented resolution. Testing for hepatitis B or other infections for eligibility will be performed only if clinically indicated.
Tumor tissue or blood collections from patients with benign tumors including desmoid tumors, carcinoma in situ, or ongoing complete disease response (CR).
Blood Only Collections
Blood will not be collected from patients whose disease demonstrates ongoing partial response or with ongoing (i.e., prolonged) stable disease given the poor rate of model generation from such samples.
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