Comparing How Stem Cells are Given to Horses with Laminitis

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For questions and more information about this study, please contact the team using the information below.
Study coordinator
Name - Dr. Larry Galuppo
Email -
Phone - (530) 752-1393

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"Help us understand more about stem cell therapy administration to horses with laminitis!"
Animal: Horses & Ponies
Keywords: laminitis, equine, horse, stem cell, stem cell therapy, MSC, allogeneic
Type: Stem Cell Study
39 Participants
Background and purpose
Degenerative disorders of the equine foot, such as laminitis are a major cause of foot lameness in horses. Unfortunately, laminitis is not only a devastating and expensive disease to treat, but there is also no true cure for the disease. Stem cell therapy is currently being examined at as a potential treatment for laminitis based on the ability of stem cells to replicate themselves, regenerate tissue, and repair damaged tissue. The purpose of this study is to assess the best administration method for mesenchymal stem cells (MSCs). The clinical use of stem cells is still in its early stages, and determination of the ideal route to administer these cells in horses affected by laminitis is worth further investigation.
What happens in this study

If you agree to let your horse participate in this study, the following will happen:

  • A brief lameness exam
  • Three stem cell injections (2-3 weeks apart) into one of three areas – the median artery of the affected leg (s), the digital palmar vein or the subcutaneous tissues of the coronary band – while under sedation

Depending on the degree and stage of the injury, a UC Davis veterinarian will either request that you to bring your horse to the Veterinary Medical Teaching Hospital (VMTH) or a UC Davis veterinarian from the research team will go to your location and administer the stem cells treatment.

Pet owner responsibilities

If you allow your horse to participate in this study, you will be responsible for bringing the horse to the clinic or agreed upon location for the injections, and informing the UC Davis researchers if your horse of any adverse effects for the 10 days following each injection.

Participation requirements

We are looking for horses diagnosed with laminitis. Please have your veterinarian contact Dr. Galuppo to see if your horse will qualify.

Benefits and risks of participating
Results from this study may help to the determine an ideal route of administration of MSCs in horses suffering from laminitis.
If you agree to participate in this study, we offer up to 30% discount on diagnostic studies (MRI, Ultrasound, and Laboratory services) associated with the administration of MSCs in your horse.
Study duration and period
Three treatments with 2 to 3 weeks in between.
Recruitment period
From April 16, 2016
UC Davis Veterinary Medical Teaching Hospital
1 Garrod Drive
Large Animal Clinic - Equine Surgery and Lameness
Davis, CA 95616
Dr. Larry Galuppo

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


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