Evaluating a new therapeutic for dogs with liver tumors
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"Help us assess a new way to deliver treatments to liver tumors in dogs"
Animal: Dogs
Keywords: liver cancer, cancer, tumor, liver, dog, canine, nanoparticle
Type: Device / Surgical Technique
12 Participants
Background and purpose
The purpose of this study is to evaluate a novel treatment option for liver tumors in dogs which involves the delivery of microbubbles (nanoparticles) into the liver tumor using an ultrasound machine.
What happens in this study

If the initial exams, tests, and procedures show that your pet can take part in the study, and you choose to enroll them, then the following will happen as part of the study:

  • Injection of a microbubbles/nanoparticles into a vein
  • Abdominal ultrasound
  • Liver tumor removal (standard of care)
Pet owner responsibilities

If you choose to let your dog participate in this study, you will be responsible for covering all costs for the diagnosis and any medical intervention if an injury occurs during the study as well as keeping all scheduled appointments.

Participation requirements

We are looking for dogs with a confirmed liver tumor.

Benefits and risks of participating
We hope that the information gained from this study will allow for us to improve outcomes for dogs with liver cancer in the future.

There are several potential complications that can occur when performing anesthesia including aspiration pneumonia and death. Potential complications associated with nanoparticle or microbubble administration are unknown, but this will be monitored closely during the study. Complications associated with liver tumor resection may include bleeding, inability to remove a tumor, and complications with the incision (bleeding, infection, seroma, dehiscence).
The study will cover the visit fee, hospitalization, ultrasound and administration of the microbubbles. The study will also provide $1500 towards the liver lobectomy surgery.
Study duration and period
Your dog will be in this study for 2 weeks. No further treatments or procedures will be performed after the first day; the subsequent 13 days, your dog will be monitored for any adverse events/complications.
Recruitment period
From March 27, 2019
UC Davis Veterinary Medical Teaching Hospital
1 Garrod Drive
Small Animal Clinic - Soft Tissue Surgery
Davis, CA 95616
Dr. Bill Culp

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


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