New Treatment for Anemia Associated with Chronic Kidney Disease in Cats
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"Help us evaluate a new treatment for anemia due to chronic kidney disease in cats!"
Animal: Cats
Age: At least 1 year of age
Healthy Pets: No
Keywords: chronic kidney disease, CKD, IRIS Stage 2, IRIS Stage 3, cat, feline, internal medicine, anemia, IRIS Stage 4
Type: Drug
36 Participants
Background and purpose
Chronic kidney disease can cause low red blood cell counts (anemia). The hormone, erythropoietin (EPO), tells the body to make red blood cells. A novel drug was designed as a new source for EPO in cats. We hope that, by increasing EPO, we will increase red blood cell numbers and have less side effects than we see in the current treatments.

The purpose of this study is to check the safety and effectiveness of this novel drug in cats with anemia caused by chronic kidney disease.
What happens in this study

If you decide you would like your cat to take part in our study, we will do the following at each visit:

  • A physical exam and blood pressure measurement
  • Collect and test urine and blood
  • Give your cat the novel drug under the skin
  • Give your cat an iron injection into the muscle (every month)
Pet owner responsibilities

You will be responsible for:

  • Bringing your cat to the VMTH for all scheduled appointments;
  • Report any changes in your cat’s behavior or health during the study to the investigators;
  • Covering medical costs beyond $1000 for side effects related to the drug;
  • Covering costs to diagnose, treat or hospitalize your cat for things that occur during the study but are not related to the study drug; and,
  • Covering any medical costs after the trial is complete.
Participation requirements

We are looking for cats diagnosed with anemia and IRIS Stage 2 to early Stage 4 chronic kidney disease that:

  • Are FeLV/FIV negative;
  • At least 1 year old;
  • Do not require daily fluid administration;
  • Have never been treated previously for anemia; and,
  • Are not pregnant, lactating or intended for breeding.

To find out if your cat qualifies, your cat will need a physical exam and collect urine and blood to run several tests.

Benefits and risks of participating
By taking part in our study, your cat's anemia could improve or resolve. The new drug could benefit other cats with chronic kidney disease in the future.

Early studies found no problems with the novel drug in healthy cats. But we don't know how or if it will work in cats with chronic kidney disease. It is possible that your cat could develop antibodies to the novel drug or high blood pressure, but we will watch your cat's health throughout the study for side effects of the drug.
The study covers the cost of the novel drug and recheck examinations and urine/bloodwork done as part of the study. If there are any side effects, the sponsor will pay up to $1000 to cover the medical costs. You may also receive financial compensation for your full participation in the study.
Study duration and period
The study will last a maximum of 6 months with visits every 7 days for 4 weeks, then every 14 days for 8 weeks and finally every 28 days for 12 weeks.
UC Davis Veterinary Medical Teaching Hospital
1 Garrod Drive
Small Animal Clinic - Internal Medicine
Davis, CA 95616
Dr. Lucy Kopecny

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


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