Non-Invasive Evaluation of Liver Steatosis, Inflammation and Fibrosis

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"Comparison of imaging techniques used to evaluate patients with liver disease"
Age:
18 to 100 years old
Gender:
Any
Healthy Volunteers:
No
Keywords:
liver disease
Type:
Radiation study
Investigator:
Description
The goal of this study is to evaluate non-invasive imaging techniques for determining liver steatosis (fat), inflammation (abnormal tissue swelling), and fibrosis (abnormal tissue scarring). In addition, the study group will be using other test measures including personal demographics, laboratory blood test results, and imaging measurements to determine the severity of NAFLD (non-alcoholic fatty liver disease), NASH (non-alcoholic steatohepatitis), inflammation, and fibrosis.
This study requires
History and Physical
Blood test
Review of previous liver biopsy
PET scan
MRI scan
Who can participate?
Inclusion Criteria:

1. Patients >18 years age

2. Patients who had or will have a liver biopsy as standard of care for fatty liver disease and have risk factors for NASH. Liver biopsy needs to be within 6 months of planned imaging.

3. Patients undergoing bariatric surgery and will have a liver biopsy as standard of care.

4. Ability to provide informed consent.


Exclusion Criteria:

1. History of alcohol abuse, chronic hepatitis B or C, or other chronic liver disease other than non-alcoholic fatty liver disease.

2. Pregnant women

3. Prisoners

4. Claustrophobic to MRI

5. Allergic to FDG dye

6. Patients who are unable to lie in the scanner for one hour
Resources
Schedule
Study duration and period
Two hours
Recruitment period
From March 16, 2016
Location
UC Davis Medical Group
2315 Stockton Boulevard
Sacramento, CA 95817
Contact
Cole Johnson
Research Topic
Conditions:
  • Non-alcoholic Fatty Liver Disease (NAFLD)
  • Non-alcoholic Steatohepatitis (NASH)

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