Oral Immunotherapy (OIT) Clinical Trial for Shrimp or Cashew Food Allergy (MOTIF Study)

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"Help us analyze how immune cells of cashew/shrimp allergic individuals change over the course of OIT"
Age: 7-55 years old
Gender:
Any
Keywords: Shrimp Allergy, Cashew Allergy, Oral Immunotherapy, OIT, Food Allergy, Desensitization
Target:
72 Participants
Investigator:
Description
The purpose of this study is to see how certain immune cells in your body behave when you are given the food you are allergic to as a form of treatment (often called Oral Immunotherapy or OIT). We hope to learn how the food allergen affects people’s immune system differently between those people who can become able to eat the food, and those who cannot. We would like to see if checking immune cells over time will help us predict if allergies will come back and how safe food allergy studies are. We also want to develop tools to help us better understand, identify, and predict how patients will respond to OIT.
This study requires
  • The study will last 70 weeks and involve 21 clinic visits.
  • Updosing visits (2-3 hours) occur every 2-3 weeks for at least the first 28 weeks.
  • The study does not involve a placebo arm and every participant will be getting active therapy
Who can participate
  • 7-55 years old
  • Suspected shrimp or cashew allergy
  • Able to comply with study requirements
Benefits and risks of participating
• You may benefit from a decrease in the sensitivity to your allergens and improve your immune protection to the offending food allergens.
• The knowledge gained from this study may aid in the advancement and understanding of food allergy and help in the development of new approaches for its treatment or prevention.
• The potential discomforts with the desensitization procedure, food challenge and OIT may include an itchy rash, hives, nausea, abdominal discomfort, vomiting, diarrhea, facial swelling, cough, stuffy, runny nose, sneezing, wheezing, and shortness of breath.
• The major risks involved include severe breathing difficulties and rarely anaphylactic shock (severe allergic reaction involving many of the above symptoms plus sudden drop in blood pressure and loss of consciousness).
Compensation
You will be paid $20 for the initial screening blood draw.
Resources
Schedule
Study duration and period
- The study will last 70 weeks and involve 21 clinic visits. - Updosing visits (2-3 hours) occur every 2-3 weeks.
Recruitment period
From June 12, 2019 to July 20, 2020
Research Topic
Conditions:
  • Cashew or Shrimp Food Allergy

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