Pilot Study for the Use of Photodynamic Therapy in the Treatment of Seborrheic Dermatitis

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"Is photodynamic therapy more effective than topical treatments in the treatment of seborrheic dermatitis?"
Age:
18 to 100 years old
Gender:
Any
Healthy Volunteers:
No
Keywords:
seborrheic dermatitis
Type:
Drug study
Investigator:
Description
This study seeks to determine the effectiveness of a new treatment method using a chemical called aminolevulinic acid (ALA), which is placed on the skin followed by blue light exposure, called, photodynamic therapy (PDT), in the treatment of seborrheic dermatitis. This study also seeks to determine how PDT alters the skin microbiome (bacteria normally found in the skin) in patients with seborrheic dermatitis before and after treatment.
This study requires
Wash face with only Dove soap
Facial photography
Swabs of facial sites
Measurement of facial sebum production rates with SebuMeter®
Application of ALA to treatment side and placebo to control side
with one hour incubation
Exposure to blue light per UC Davis Dept of Dermatology standard protocol
Who can participate?
Inclusion Criteria:

- Healthy subjects 18 years or older with seborrheic dermatitis of the face will be included.


Exclusion Criteria:

- Subjects who are taking systemic corticosteroids (at doses of prednisone greater than or equal to 5 mg daily), antibiotics (PO, IM or IV) or using topical anti- fungals, steroids, antibiotics, permethrin, or calcineurin inhibitors within 2 weeks prior to the study will be excluded.

- The exclusion criteria will also include the presence of other untreated inflammatory conditions (such as lupus, atopic dermatitis, or psoriasis) or untreated malignancies on the face (including skin cancers such as basal cell carcinoma, squamous cell carcinoma and melanoma).

- Any subjects with known or suspected hypersensitivity to any constituent of the study medication or a history of photosensitivity due to conditions such as lupus erythematosus and porphyria will be excluded.

- Subjects who have had photodynamic therapy (PDT) to the face for any reason within the past year will be excluded as well.

- Adults unable to consent, individuals under the age of 18, pregnant or breastfeeding women and prisoners will be excluded from the study.
Compensation
Upon completion of both visit 1 and visit 2, $40.
Upon completion of visit 3, $20
We will make the payments using gift cards
Resources
Schedule
Study duration and period
Three months
Recruitment period
From Aug. 2, 2014
Location
UC Davis Department of Dermatology
3301 C Street
Suite 1300
Sacramento, CA 95816
Contact
Parastoo Davari, MD
Research Topic
Conditions:
  • Seborrheic Dermatitis

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