Resistant Starch Wheat for Improved Metabolic Health

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"Does Resistant starch (RS), starch that escapes from digestion in the small intestine of healthy individuals, increase good bacteria in gut?"
Age:
40 to 65 years old
Gender:
Any
Healthy Volunteers:
Yes
Keywords:
gut microbiota, metabolism, metabolic health
Type:
Dietary Supplement study
Investigator:
Description
The objective of this study is to determine the effect of wheat containing resistant starch (RS) on the gut microbiota, intestinal metabolites, and the glycemic response compared to regular wheat. Resistant starch (RS) is starch that escapes from digestion in the small intestine of healthy individuals
This study requires
This research study includes an orientation visit that will take place about 1-2 weeks before the study and will require about 2 hours of your time. During this visit, we will go through the consent process with you, take physical measurements (i.e. height, weight, waist & hip circumference, blood pressure), obtain a blood sample, and give you questionnaires to fill out on your health history, eating habits, and physical activity habits. Once the study begins, the time you will be enrolled will be about 1 month. During the month the following activities will be scheduled:
1. You will drop off your first stool specimen at the Western Human Nutrition Research Center (WHNRC) and pick up your supply of provided wheat products.
2. For seven days, you will consume the provided wheat products with your usual diet.
3. During the seven days, we will ask that you fill out a log of your bowel movements, recording the approximate time/date on a log sheet we provide along with a description of its appearance.
4. During the seven days we will contact you and ask you to do a 24-hour recall. This will happen twice and the selected recalls days will be random – not scheduled in advance.
5. On the sixth or seventh day, we will ask that you collect another stool sample.
6. Following the seventh day (day 8) you will be scheduled for your first test day. This test day will be scheduled in the morning, and will be about 4 hours long.
7. For the next two weeks, you will be in a “washout period.” This means that you won’t be eating any study-provided wheat products and you will continue your usual diet. At the end of the washout period, you will collect another stool sample.
8. You will drop off this third stool specimen at the Western Human Nutrition Research Center (WHNRC) and pick up your supply of provided wheat products for the next wheat product period.
9. For seven days, you will consume this supply of provided wheat products with your usual diet.
10. As before, during the seven days, we will ask that you fill out a log of your bowel movements, recording the approximate time/date on a log sheet we provide along with a description of its appearance.
11. As before, during the seven days we will contact you and ask you to do a 24-hour recall. This will happen twice and the selected recalls days will be random – not scheduled in advance.
12. On the sixth or seventh day of this week, we will ask that you collect your final stool sample.
13. Following the last day of this week you will be scheduled for your second test day. As before, this test day will be scheduled in the morning, and will be about 4 hours long.
14. At the end of this test day, you will have completed the study.
All test visits, stool drop-offs, and wheat product pick-up will take place at the Western Human Nutrition Research Center on the UC Davis campus (430 West Health Sciences Dr., Davis, CA 95616).
Who can participate?
Inclusion Criteria:

- Healthy adults. Healthy means that the candidate reports that s/he feels well and can perform normal activities.


Exclusion Criteria:

- BMI 39.9 kg/m2

- Presence of of untreated or uncontrolled metabolic diseases

- Presence of gastrointestinal disorders that could interfere with the study outcome (i.e. Crohn's disease, Irritable bowel syndrome, Colitis)

- Use of oral antibiotics within the past 3 months

- Presence of cancer or other serious chronic disease by self report

- Current use of prescribed or over the counter weight loss medications

- Pregnant

- Lactating

- Current use of tobacco

- Dietary restrictions that would interfere with consuming the intervention foods
Compensation
If you agree to take part in this research study, we will compensate you up to $200 for your time and effort.

This amount is dependent upon completion of study protocols. If you don’t complete all study protocols or withdrawal from the study early, your compensation will be pro-rated accordingly:
Study Test Days $75 per test day (2 test days) = $150
Fecal samples, $5 per sample (4 samples)
= $20
24-hour recalls, $5 per recall (6 recalls)
= $30
Resources
Schedule
Study duration and period
Approximately one month
Recruitment period
From Jan. 26, 2017
Location
Western Health Nutrition Research Center
1 Shields Avenue
430 West Health Drive
Davis, CA 95616
Research Topic
Conditions:
  • Gut Microbiota
  • Metabolism
  • Metabolic Health

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


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