4 to 17 years old
Drug study, Phase 4
Acetaminophen study dose administration Two blood draws through IV (one while under anesthesia)
Patients having additional procedures or surgical interventions
Patients who meet UCDCH criteria for PICU admission: on home oxygen pre-operatively, exhibit airway obstruction when awake (stertor above larynx, stridor at larynx), sleep study with apnea hypoxia index greater than 25 or sleep oxygen saturation nadir <80%, cardiac disease, difficult intubation.
Patients with a known allergy to acetaminophen
Patients with known hepatic insufficiency or severe hepatic disease
Patients with known G6PD deficiency
Patients who are malnourished (ie lower levels of glutathione)
Patients with severe renal impairment as defined by calculated creatinine clearance <20 ml/min (per modified Schwarz equation)
Patients who are pregnant
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