18 to 100 years old
heart failure, heart attack, vaccine
Biological study, Phase 4
Medical history Blood draws Vaccine administration Seven day vaccine diary completion Follow up contact
= 18 years of age
history of hospitalization for myocardial infarction within 1 year of enrollment OR a history of hospitalization for heart failure within 2 years of enrollment
At least one of the following additional risk factors:
Prior MI (if HF the index event above; or a second MI)
Prior HF hospitalization (if MI the index event above; or a second HF event)
Age ≥ 65
LVEF < 40%
Obesity (BMI ≥ 30)
Renal impairment (eGFR ≤ 60)
History of ischemic stroke
History of peripheral artery disease
Known allergy, hypersensitivity (anaphylaxis), or Guillain-Barré Syndrome within 6 weeks after influenza vaccine
Any non-cardiac condition that in the opinion of the investigator would lead to life expectancy less than 9 months.
Receipt of influenza vaccine during current influenza season
Any illness requiring treatment with antibiotics or anti-inflammatory medication within the past 14 days.
Any fever over 100 degrees Fahrenheit or 38 degrees Celsius within the past 7 days.
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