Study of Immune Response to Pneumococcal Vaccine in Splenic Injury Patients

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"How effective is vaccination in those who have sustained an injury to their spleen or undergone a surgical procedure to remove their spleen?"
Age:
18 to 65 years old
Gender:
Any
Healthy Volunteers:
No
Keywords:
spleen dysfunction, asplenia, vaccine
Type:
Biological study
Investigator:
Description
One of the purposes of the spleen is to produce substances known as antibodies that help protect you against certain types of bacteria, the most common of which is one that causes pneumonia. People without spleens or who have inadequately functioning spleens are unable to produce the antibodies normally. To protect against infection, patients at the University of California, Davis Medical Center who have suffered injuries to their spleen are routinely given a vaccine called Pneumovax®. With this study, we hope to learn more about patients whose spleen has been removed or made at least partially nonfunctional by the injury, and their ability to protect themselves with antibodies against the bacteria.

You are being asked to be a subject in this research study to determine how effective vaccination is in people who have sustained an injury to their spleen and have undergone a surgical procedure to remove your spleen (splenectomy). If it was injured and bleeding but you were stable enough to have a radiologist block the bleeding artery, your procedure is called embolization. If your spleen was damaged but was not actively bleeding, you have been under close observation only, known as nonoperative management. The purpose of this study is to investigate the antibody response to pneumococcal vaccine in patients undergoing these modes of therapy.
This study requires
If your injury to your spleen was treated non-operatively, then you will receive a vaccination shortly after your diagnosis. If you underwent embolization or splenectomy surgery, then you will be scheduled to receive a vaccination about 14 days after that surgical date.

Blood draw before vaccination and four weeks later

Access to your medical records during the study to review your operative procedures, CT Scans, medical history and previous vaccinations. This review and all data obtained will be protected to the greatest degree possible.
Who can participate?
Inclusion Criteria:

- Adult trauma patients (aged 18 to 65 years old) sustaining a splenic injury.


Exclusion Criteria:

- Ages less than 18 and greater than 65

- Initial planned nonoperative management patient who subsequently undergoes embolization or splenectomy will be withdrawn from the study.
Resources
Schedule
Study duration and period
One month
Recruitment period
From June 27, 2017
Location
UC Davis Department of Surgery
2221 Stockton Boulevard
Sacramento, CA 95817
Contact
Chancey Sweeney
Research Topic
Conditions:
  • Asplenia

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


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