Study of safety and feasibility of personalized radiotherapy

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"Personalized radiotherapy with four-dimensional (4D) computed tomography (CT)-based pulmonary ventilation imaging to treat lung cancer"
Age:
18 to 80 years old
Gender:
Any
Healthy Volunteers:
No
Keywords:
radiation, radiotherapy, lung cancer, cancer
Type:
Radiation study
Investigator:
Description
This study will assess the safety and feasibility of personalized radiotherapy with four-dimensional (4D) computed tomography (CT)-based pulmonary ventilation imaging, which selectively avoids irradiating highly-functional lung regions.
This study requires
History and Physical
Blood tests
Respiratory tests
CT Scans
Radiotherapy
Who can participate?
Inclusion Criteria:

- Primary lung cancer or metastatic disease to the lungs to be treated with either conventionally-fractionated radiotherapy (CFRT) or hypo-fractionated stereotactic ablative radiotherapy (SABR).

- Age restriction and/or gender/ethnic restrictions: Patients must be ≥18 years of age. There are no gender or ethnic restrictions.

- Concurrent chemotherapy is allowed, but not required.

- Life expectancy with treatment should be ≥6 months in the estimation of the treating physicians.

- Zubrod performance status ≤2

- Adequate marrow and hepatic function defined as Hgb ≥8; platelets ≥100k; ANC≥1500; LFTs ≤2x upper limit of normal and creatinine ≤1.3 or creatinine clearance of ≥50

- Patient must be able to provide study specific informed consent prior to study entry.


Exclusion Criteria:

- Prior radiotherapy for thoracic cancer or other malignancy leading to any overlap of planned radiotherapy fields.

- For patients undergoing definitive CFRT, patients with distant metastatic disease are not eligible.

- For patients undergoing SABR, both early stage primary lung cancer patients and those with limited metastatic disease to the lungs are eligible; however, patients with oligometastatic disease should have a controlled primary and no more than one other involved organ system.

- Children (<18 years of age), pregnant women, University of California employees or students, or prisoners will be excluded from this study.
Resources
Schedule
Study duration and period
Study treatment and procedures: 3-8 weeks Follow up: every 3 months for 2 years
Recruitment period
From Aug. 27, 2013
Location
UC Davis Comprehensive Cancer Center
2279 45th Street
Sacramento, CA 95817
Contact
Heather Melanson
Research Topic
Conditions:
  • Lung Cancer

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