18 to 100 years old
burn, burn injury
Dietary Supplement study, Phase 3
Supplementation of NHP or placebo either through diet or feeding tube while in ICU/burn unit Questionnaires completed after discharge
Deep 2nd and/or 3rd degree burns requiring grafting
a.) Patients 18 - 59 years of age without inhalation injury TBSA ≥ 20% b.) Patients 18 - 59 years of age with inhalation injury TBSA ≥ 15% c.) Patients ≥ 60 years of age (with or without inhalation injury) TBSA* ≥ 10%
TBSA - Total Burn Surface Area
72 hrs from admission to ICU to time of consent.
Patients younger than 18 years of age
In patients without known renal disease, renal dysfunction defined as a serum creatinine >171 µmol/L or a urine output of less than 500 ml/last 24 hours (or 80 ml/last 4 hours if a 24 hour period of observation is not available). In patients with acute on chronic renal failure (pre-dialysis), an absolute increase of >80 µmol/L from baseline or pre-admission creatinine or a urine output of <500 ml/last 24 hours (or 80 ml/last 4 hours) will be required. Patients with chronic renal failure on dialysis will be excluded.
Liver cirrhosis - Child's class C liver disease
Absolute contra-indication for EN: intestinal occlusion or perforation, abdominal injury
Patients with injuries from high voltage electrical shock
Patients who are moribund
Patients with extreme body sizes: BMI 50
Enrolment in another industry sponsored ICU intervention study
Received glutamine supplement for > 24 hrs prior to randomization
Known allergy to maltodextrin, corn starch, corn, corn products or glutamine
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