The Watch the Spot Trial

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For questions and more information about this study, please contact the team using the information below.
Study coordinator
Name - Evan de Bie
Email -
Phone - (530) 752-4726

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"Help us find the best timing for CT scans to keep an eye on small lung nodules."
Age: 35 years or older
Healthy Volunteers: No
Keywords: lung, cancer, nodules, CT, scan
Type: Other study
Each year, over 1 million Americans learn that they have a potentially cancerous lung nodule. These are usually found by chance on a chest x-ray or chest CT scan.

Lung cancer screening is now recommended for high-risk smokers and former smokers. This helps detect lung nodules earlier, when it is more treatable. Cancerous nodules can be cured with surgery when promptly diagnosed and treated.

Fewer than 5% of nodules prove to be cancerous. A key question is how to distinguish malignant nodules from benign ones. Small nodules measuring up to 15 mm are difficult to biopsy or remove.

The default option for evaluation is a series of CT scans to identify growth that is suggestive of cancer. The best time-frame of surveillance has never been determined.

This study will compare more intensive vs. less intensive surveillance in patients with small pulmonary nodule(s) on chest CT.
This study requires

The study team will make sure you qualify to take part in the study. Qualified participants will receive detailed information about the study. This may include a list of study-related tests and procedures.

Who can participate

Inclusion Criteria:

The target population includes adults with small lung nodules that may represent a new diagnosis of lung cancer, who typically would be managed by CT surveillance in usual clinical practice. Thus, we will enroll all patients:

  • aged ≥35 years

  • at least one nodule measuring ≤15 mm in average diameter on chest CT.

Exclusion Criteria:

  • Pregnant Women

  • Age <35 years

  • Known diagnosis of cancer (except non-melanoma skin cancer) within 5 years

Benefits and risks of participating

We cannot promise any benefits to you as a result of taking part in this research study.


The study doctor will discuss the risks associated with taking part in this research study.
You will not be paid to take part in this research study.
Study duration and period
Please contact us for study details.
Recruitment period
From March 15, 2017
UC Davis Comprehensive Cancer Center
4501 X Street
Sacramento, CA 95817
Research Topic
  • Solitary Pulmonary Nodule
  • Coin Lesion
  • Pulmonary
  • Lung Neoplasms
  • Carcinoma
  • Non-small-cell Lung

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


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