Using stem cells to help cats with gingivostomatitis after having received a full dental extraction
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"Help us treat cats with gingivostomatitis!"
Animal: Cats
Healthy Pets: No
Keywords: feline gingivostomatitis, gingivostomatitis, lesion, feline, cat, FCGS, feline chronic gingivostomatitis, stem cell, stem cell therapy, treatment, dentistry, dentistry and oral surgery
Type: Stem Cell Study
16 Participants
Background and purpose
Feline chronic gingivostomatitis (FCGS) is a painful disease in cats that needs medical or surgical treatments. A stem cell therapy where stem cells are taken from fat tissue is a new potential therapy for chronic inflammatory diseases. This cell therapy MAY help to correct abnormalities that may be involved with stomatitis in cats. Moreover, stem cells may help in regenerating damaged tissues. In this study, we will evaluate the effectiveness of using stem cells to treat cats with gingivostomatitis that have had full or near-full mouth extractions.
What happens in this study
  • Collect blood for analysis before the treatment and at the recheck appointments;
  • Obtain an oral biopsy while under anesthesia at the first and last appointment;
  • Surgically collect fat from the area under the belly skin behind the navel to produce stem cells;
  • Administer the stem cells to your cat systemically two times in 4 weeks (possibly under sedation) while being hospitalized; and,
  • Get a biopsy from the healed oral mucosa if needed.
Pet owner responsibilities

If you allow your cat to participate in this study, you will be responsible for bringing your cat to all appointments. Please note that working with stem cells requires flexibility in your schedule as the rate of cell division (proliferation) is not precisely predictable.

Additionally, you will need to pay for the take-home medication, dental x-rays, periodontal treatment and extractions if/as needed. If your cat needs medical treatment because a problem occurred during the study, you will be responsible for the costs.

Participation requirements

We are looking for cats diagnosed with gingivostomatitis that are otherwise healthy, have undergone full or near-full mouth tooth extractions and have pain and discomfort with or without ongoing medical therapy (antibiotics and/or corticosteroids).

Benefits and risks of participating
Participating in your study may resolve your cat's gingivostomatitis which can change the quality of life of your cat. If this study will prove to be beneficial, it will have important clinical applications for other cats with the same condition. Moreover, it is possible that if proven beneficial, this treatment can be introduced to human medicine for similar indications.

Your cat may have IV site swelling, pain, or heat, formation of a blood clot inside a blood vessel (thrombus formation), an allergic reaction, bleeding in the mouth, swelling, bleeding or bruising when blood is collected and/or, infection at the site of biopsy or IV.

This treatment is experimental. Besides to these risks, this study may affect your cat in ways that are unknown.
The study will cover the blood work, hospitalization, the stem-cells administration, and recheck exam fees.
Study duration and period
We expect that participation in this clinical trial will last for 6 months. It is required that we treat your cat with stem cells two times (4 weeks between treatment) and see your cat for a recheck at 1, 3 and 6 months after the first stem cell treatment.
Recruitment period
From Jan. 28, 2016
UC Davis Veterinary Medical Teaching Hospital
1 Garrod Drive
Small Animal Clinic - Dentistry and Oral Surgery
Davis, CA 95616

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


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