Ventricular Septal Defects in Arabian Horses

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"Help us find out what genes cause Ventricular Septal Defects in Arabian horses!"
Animal: Horses & Ponies
Keywords: arabian, horse, arabian horse, ventricular septal defect, equine
Type: Genetic Study
Target:
87 Participants
Investigator:
Background and purpose
Ventricular Septal Defects (VSDs) are the most common congenital heart defects in horses. They allow blood to shunt inappropriately from the left ventricle to the right ventricle via an opening in the ventricular septum. This blood recirculates through the lungs and left chambers, resulting in enlargement of these structures. Arabian horses are overrepresented in horses presenting for VSDs, and we are investigating the possibility of a genetic predisposition for this defect.
What happens in this study

To participate in the study, we will need you or your veterinarian to collect and submit a blood sample (3ml in an EDTA purple top) for DNA extraction by the cardiac genetics laboratory.

Pet owner responsibilities

If you are willing to have your horse participate, we will need you or your veterinarian to collect and submit a blood sample. If your Arabian was diagnosed with a heart murmur but you are unsure whether it qualifies for the study, please contact us. In some cases, we may be able to review your horse's medical records or even fund a cardiac examination for your horse.

Participation requirements

We are looking for Arabian horses or Arabian crosses that have a right-sided systolic heart murmur, or a veterinary diagnosis of ventricular septal defects. Horses must tolerate handling and stand for the echocardiogram.

Benefits and risks of participating
Results from this study will determine if a genetic factor plays a role in the development of Ventricular Septal Defects in Arabian horses. This finding would have great significance regarding screening predisposed horses and hopefully guiding breeding management to avoid continuation of this defect in the Arabian horse.
Resources
PDF Docs
Clinical Trial Informational Flyer
Schedule
Study duration and period
The time it takes to collect and send a blood sample
Recruitment period
From July 13, 2017
Location
Stern Laboratory - UC Davis
1 Shields Avenue
2108 Tupper Hall
Davis, CA 95616

Have any questions or want to learn more? Leave your contact details below and the research team will reach out to you.


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