UC Davis Health Clinical Studies

Learn about a study of emergency care in patients with traumatic brain injury.

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BOOST3 is a research study to learn if either of two strategies for monitoring and treating patients with TBI in the intensive care unit (ICU) is more likely to help them get better. Both of these alternative strategies are used in standard care. It is unknown if one is more effective than the other. In one strategy doctors concentrate only on preventing high ICP (intracranial pressure) caused by a swollen brain. In the other strategy doctors try to prevent high ICP, and also try to prevent low PbtO2 (brain oxygen). It is unknown if measuring and treating low brain oxygen is more effective, less effective, or the same as monitoring and treating high brain pressure alone. The results of this study will help doctors discover if one of these methods is more safe and effective.

Interventional
Any, age 14 and older

Are you experiencing sciatica (leg pain), from a herniated disc?

Please consider joining this clinical research study examining the effectiveness of an investigational drug injection for leg pain.

The goal of this clinical trial is to test if a single injection in the spinal disc works well. The investigational injection will be tested in patients with lumbar disc herniation (LDH). Lumbar disc herniation (LDH) is very common and happens when the soft center of a spinal disc bulges out. This bulging can compress nearby nerves causing pain, numbness, or weakness in a leg. This study is conducted at the UC Davis Spine Center. You will receive all study medication, or control injection and study evaluations at no cost, and compensation for your time is available.

Drug study, Phase 3
Any, age 30-70 years

Clinical Trial of Experimental LimiFlex for Treating Degenerative Spondylolisthesis With Spinal Stenosis (narrowing of the spine)

UC Davis is participating in the Control Arm for this study. Website: https://limiflextrial.com/

Degenerative spondylolisthesis is when one of the bones in your spine has moved forward in relation to the vertebra below it. Degenerative spondylolisthesis can cause or worsen lumbar spinal stenosis. This is a narrowing of one or more areas in the lower part of your spine. This narrowing can put pressure on the spinal cord or spinal nerves and cause pain, numbness or weakness in your legs, back, or buttocks. To treat your condition, your doctor is recommending spinal surgery. Before patients are enrolled into this study, doctor offices will be considered a Control Site or an Investigative Site. All patients will be offered posterior decompression surgery to help relieve abnormal pressure on nerves that are causing the pain and discomfort. This standard of care surgery is also called laminectomy. During the decompression surgery, your doctor will remove the bone in your spine that is causing your pain. The purpose of the decompression surgery is to help relieve abnormal pressure on your nerves that is causing pain and discomfort. Dr. Kim and University of California Davis Health will be considered a Control Site. After the decompression, patients at the Control Sites will have a procedure called spinal fusion. This surgery is also called a transforaminal lumbar interbody fusion (TLIF) with posterolateral fusion (PLF) or a posterior decompression surgery with spinal fusion. In the spinal fusion procedure, bone is placed around the vertebrae to cause the vertebra to connect so that they behave and move as one block. This is called a posterior (done from the back) lumbar fusion and is done to help stabilize the spine.

Device study
Any, age 25 to 80 years old