UC Davis Health Clinical Studies

Cognitive Training for Fragile X Syndrome

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

Individuals with fragile X syndrome (FXS) demonstrate profound executive function deficits that interfere with learning, socialization and emotion regulation. Extensive research focused on the animal models of FXS show that targeted pharmacological agents can normalize synaptic connectivity and reverse cognitive and behavioral deficits. This translational work has led to multiple national and international controlled trials in humans with FXS now underway. However, in contrast to the heavy focus on medication treatments, there have been no controlled trials to empirically-validate cognitive or behavioral interventions for FXS. The proposed study, the first non-pharmacological controlled trial for FXS, will evaluate the efficacy of Cogmed, a cognitive training program proven to enhance working memory and executive/frontal function in a variety of clinical populations. Demonstration of effective Cogmed training for FXS would represent a major advance in the field, one that may also generalize to other forms of intellectual disability. Furthermore, it is critical to determine whether the targeted pharmacological treatments can accelerate learning and cognitive development. Thus, the validation of Cogmed for FXS will provide a paradigm for testing hypotheses focused on combined efficacy of medication and cognitive training.

Other study
Any, age 8 to 18 years old

HELP SPEED UP AUTISM RESEARCH

Join SPARK Today

SPARK, a new online research initiative, aims to advance our understanding of autism by transforming the research landscape. SPARK, a landmark research partnership, will connect researchers to a large group of individuals with autism and their biological families. SPARK is a free online study with a simple mission: to speed up research and advance the understanding of autism • SPARK aims to be the largest study of its kind with the goal of building a community of 50,000 individuals with autism and their families across the nation • The entire autism community is encouraged to participate, including adults and children diagnosed with autism, as well as their biological parents and siblings • By dramatically increasing the number of research participants, SPARK aims to help facilitate research that has not yet been possible An important part of SPARK is the collection of DNA so it can be analyzed to expand our understanding of the role of specific genes in the development of autism. SPARK will ask you to share basic information about your medical and family history, and if you choose, a DNA sample using a saliva collection kit.

Genetic Database
Any, age all individuals with Autism Spectrum Disorder(ASD)
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