UC Davis Health Clinical Studies

A Study of Stratification and Algorithm in Opioid Use in Shoulder Arthroplasty Patients

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

We aim to better understand opioid use in patients having elective shoulder surgery. We plan to use a teaching session and pain contract to decrease opioid use after surgery. We hope to create a method for physicians to efficiently manage pain after surgery without causing opioid dependency. Elective shoulder surgery is on the rise, along with increased use of TSA in elderly patients. The need for determining optimal management without overprescribing narcotics has become very important. Decreased opioid use would mean decreased chance of having unwanted side effects of too much opioids. This inlcudes: - respiratory depression - nausea - sedation - driving restrictions - use by unintended individuals

Behavioral study
Any, age 18 years or older

A Study Comparing Experimental Antibiotic Therapies in Tumor Surgery (PARITY Study)

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

You are being asked to take part in this study because you have: - a bone tumor - soft-tissue sarcoma (cancer) - metastatic bone disease (cancer that has invaded the bone or spread outside the primary cancer area). Your condition requires surgery to be removed and a prosthetic implant to be inserted in its place. Patients with tumor prostheses (implants) are at risk for developing an infection. Up to 1 out of 10 tumor prostheses may become infected given that the wound is relatively large and the procedure is fairly long and extensive. Surgeons can decrease the risk of infection with the use of antibiotics before, during, and after surgery. Not all surgeons agree on how long antibiotics should be given after surgery. Some surgeons believe that giving antibiotics for 5 days after surgery is best for preventing infections. Other surgeons believe that 5 days is too long. They believe 24 hours is just as effective at preventing infection while reducing the risk of antibiotic resistance. The purpose of this study is to determine which antibiotic regimen (therapy) after surgery (24 hours or 5 days) is more effective. The study team will look at the antibiotic's effect on reducing surgical site infection.

Drug study, Phase 3
Any, age 12 years or older

A Study of the Safety and Effectiveness of Experimental Medicine Vamorolone in Boys With Duchenne Muscular Dystrophy (DMD)

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

The purpose of this research is to see if an experimental drug called vamorolone is effective and has fewer side effects than steroids. It will be studied in children with Duchenne muscular dystrophy (DMD). Boys with DMD experience progressive muscle weakness as they grow up. Steroids such as prednisone (or prednisolone) and deflazacort, are currently the only class of medication available to all boys with DMD. These medicines have been shown to prolong walking ability. Steroids have several side effects. Side effects include weight gain, behavioral problems, growth restriction, increased risk of bone fractures. We are doing this research study to see if vamorolone works in DMD and if it has fewer of these side effects.

Drug study, Phase 2
Male, age 4 to 7 years old

A Study of Experimental Medicine ADS-5102 For Multiple Sclerosis and Walking Impairment

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

The purpose of this study is to look at the long-term safety and efficiency of experimental ADS-5102. It will be studied in patients with multiple sclerosis (MS) with walking impairment. "Experimental" means the study drug formulation being tested is not approved by the FDA. The active ingredient in ADS-5102 is called amantadine. Amantadine is FDA approved to help prevent and treat signs and symptoms of infection caused by some forms of the influenza virus. It is also approved as a treatment for Parkinson’s disease and other nervous system disorders. ADS-5102 is a formulation of amantadine that allows the drug to be taken up by the body slowly. This kind of formulation is called an extended release (ER) formulation. This allows the drug to be taken once a day. In MS, neurons of the central nervous system are damaged due to inflammation, and the communication of one neuron to another is impaired. Amantadine may improve the communication between neurons that has been impaired due to MS. Thereby, improve the central nervous system’s control of walking.

Drug study, Phase 3
Any, age 18 to 70 years old
Loading