UC Davis Health Clinical Studies

HIV Post-Exposure Prophylaxis Uptake and Adherence Post-Sexual Assault

Looking for men and women who have been offered medications to prevent HIV following sexual assault

Thank you for your interest in taking part in the My Experiences Navigating Daily-life (MEND) research study. The purpose of this study is to get information about how and why people do or do not take HIV post-exposure prophylaxis (PEP) (medications to prevent HIV) in the four weeks after a sexual assault. Your participation will involve taking a survey via an internet-based web-application. Completing this survey means you consent to participate in this study. There are two parts to the survey: a screening section and the main survey. After finishing the screening section, you may or may not be selected to complete the main survey. The main survey will take about 30-45 minutes to complete. You can complete the survey two ways: (1) anonymously, or (2) you may choose to provide your email address to receive a gift card for your time.

Online survey
Any, age 18+

Cognitive Training for Fragile X Syndrome

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

Individuals with fragile X syndrome (FXS) demonstrate profound executive function deficits that interfere with learning, socialization and emotion regulation. Extensive research focused on the animal models of FXS show that targeted pharmacological agents can normalize synaptic connectivity and reverse cognitive and behavioral deficits. This translational work has led to multiple national and international controlled trials in humans with FXS now underway. However, in contrast to the heavy focus on medication treatments, there have been no controlled trials to empirically-validate cognitive or behavioral interventions for FXS. The proposed study, the first non-pharmacological controlled trial for FXS, will evaluate the efficacy of Cogmed, a cognitive training program proven to enhance working memory and executive/frontal function in a variety of clinical populations. Demonstration of effective Cogmed training for FXS would represent a major advance in the field, one that may also generalize to other forms of intellectual disability. Furthermore, it is critical to determine whether the targeted pharmacological treatments can accelerate learning and cognitive development. Thus, the validation of Cogmed for FXS will provide a paradigm for testing hypotheses focused on combined efficacy of medication and cognitive training.

Other study
Any, age 8 to 18 years old

The BRAIN Study

Studying different patterns of brain development in children

Autism is a very complex disorder, and it is likely that various subtypes exist. For over 10 years, investigators at the MIND Institute have been trying to define different subtypes or “phenotypes” of autism in order to develop the best treatments for each type. As part of this effort, we have been examining the brains of children with autism and age matched typically developing kids to see if there are different patterns of development and organization. In our previous work, we have found that about 15% of boys with ASD have a large brain form of autism. Besides a big brain, we have found that these kids have a different behavioral profile than other kids with ASD. On average, they showed fewer gains in IQ and language by age 5. However, some children with ASD and a big brain showed gains instead. The primary goal of this project is to further study the large brain ASD children compared to other children with and without ASD.

Other
Any, age 24- 42 months
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