UC Davis Health Clinical Studies

Are you experiencing sciatica (leg pain), from a herniated disc?

Please consider joining this clinical research study examining the effectiveness of an investigational drug injection for leg pain.

The goal of this clinical trial is to test if a single injection in the spinal disc works well. The investigational injection will be tested in patients with lumbar disc herniation (LDH). Lumbar disc herniation (LDH) is very common and happens when the soft center of a spinal disc bulges out. This bulging can compress nearby nerves causing pain, numbness, or weakness in a leg. This study is conducted at the UC Davis Spine Center. You will receive all study medication, or control injection and study evaluations at no cost, and compensation for your time is available.

Drug study, Phase 3
Any, age 30-70 years

Do you have damaged knee cartilage? Participate in a research study

We want to find out if a new experimental surgical procedure is safe and effective for knee cartilage damage

We invite people with cartilage damage of the knee to participate in this research study. This study will compare an experimental procedure with a standard treatment for knee cartilage damage. Cartilage damage of the knee happens when the protective soft tissue at the ends of bones (cartilage) wears down. This process occurs slowly and worsens over time. In this study you may receive one of two possible surgical procedures. One procedure is the investigational Novocart® 3D cartilage implant system. This implant system uses your own cartilage cells. The cells are grown outside your body in a lab. They are then introduced into your injured knee to re-grow and fill in the injured area. The other possible procedure is called Microfracture. It is one of the standard treatments for knee cartilage damage. The Novocart® 3D cartilage implant system has not received approval in the US but has been on the market in Europe as an Advanced Therapy Medicinal Product since 2003. This clinical research study happens at the Department of Orthopaedic Surgery at UC Davis. You will receive certain research procedures at no cost and compensation for your time is available. Sign up to learn more.

Procedure study, Phase 3
Any, age 18 to 65 years old

An Observational Study of Acute Burn Resuscitation (fluid infusion)

This is an observational study focusing on patients admitted to the burn center at UC Davis Medical Center.

This observational study will involve real-time data collection. It will focus on patients admitted to the burn center at UC Davis Medical Center. The team will study patients receiving fluid resuscitation during the first 48 hours after burn injury. Data collected will include fluid infusion rates, vital signs, and laboratory values. All procedures will follow UC Davis Medical Center's standard of care. Data on outcomes (organ function, ventilation duration, length of stay, and survival) will be collected at 72 hours, 96 hours, and at hospital discharge.

Observational Study
Any, age 18 years or older

Clinical Trial of Experimental LimiFlex for Treating Degenerative Spondylolisthesis With Spinal Stenosis (narrowing of the spine)

UC Davis is participating in the Control Arm for this study. Website: https://limiflextrial.com/

Degenerative spondylolisthesis is when one of the bones in your spine has moved forward in relation to the vertebra below it. Degenerative spondylolisthesis can cause or worsen lumbar spinal stenosis. This is a narrowing of one or more areas in the lower part of your spine. This narrowing can put pressure on the spinal cord or spinal nerves and cause pain, numbness or weakness in your legs, back, or buttocks. To treat your condition, your doctor is recommending spinal surgery. Before patients are enrolled into this study, doctor offices will be considered a Control Site or an Investigative Site. All patients will be offered posterior decompression surgery to help relieve abnormal pressure on nerves that are causing the pain and discomfort. This standard of care surgery is also called laminectomy. During the decompression surgery, your doctor will remove the bone in your spine that is causing your pain. The purpose of the decompression surgery is to help relieve abnormal pressure on your nerves that is causing pain and discomfort. Dr. Kim and University of California Davis Health will be considered a Control Site. After the decompression, patients at the Control Sites will have a procedure called spinal fusion. This surgery is also called a transforaminal lumbar interbody fusion (TLIF) with posterolateral fusion (PLF) or a posterior decompression surgery with spinal fusion. In the spinal fusion procedure, bone is placed around the vertebrae to cause the vertebra to connect so that they behave and move as one block. This is called a posterior (done from the back) lumbar fusion and is done to help stabilize the spine.

Device study
Any, age 25 to 80 years old
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