UC Davis Health Clinical Studies

Use of Hypertonic Saline (a concentrated salt solution) After Abdominal Trauma Surgery to Improve Wound Healing

This study will look at using a concentrated salt solution versus standard salt solution in IV's given after abdominal trauma surgery.

This study will examine using hypertonic saline (a concentrated salt solution). The study team wants to learn if it is better than standard intravenous (given through a vein) salt solutions. It will be used after abdominal trauma. We are investigating whether using hypertonic saline will improve wound healing. We hope it will also result in less injury to organs in the abdomen and decreased time in the ICU and/or the hospital.

Procedure study
Any, age 18 years or older

Experimental Medicine Letermovir To Prevent Human Cytomegalovirus (CMV) Disease in Adult Kidney Transplant Recipients

This study will help determine whether an experimental drug, letermovir, is a safe and effective to prevent CMV infections.

CMV commonly infects humans. In the US, it’s estimated that 50-80% of the population has been infected with CMV by 40 years of age. While common, CMV infection is usually asymptomatic or has mild symptoms in healthy adults. However, serious disease occurs almost entirely in individuals who are immunocompromised. For example, in kidney transplant patients. There is currently no cure or vaccine for CMV. In order to prevent CMV infections, this study will help determine whether an experimental drug, letermovir, is a safe and effective preventative treatment for transplant recipients. We want to know if there are any unwanted effects on your health related to the use of letermovir. In this study, letermovir will be compared to a current FDA approved drug, valganciclovir, to prevent CMV infections. In addition, you may receive acyclovir to prevent other viral infections. Letermovir has been approved in the USA and other countries for use in certain transplant patients. It may not be approved for your type of transplant.

Drug study, Phase 3
Any, age 18 years or older

Topical Clobetasol for the Treatment of Toxic Epidermal Necrolysis

Treatment of toxic epidermal necrolysis/Stevens-Johnson’s Syndrome with topical steroid to characterize the genetic makeup of the disease.

We invite you or your child to take part in a research study because you or your child had a biopsy showing that you/they are suffering from toxic epidermal necrolysis/Stevens-Johnson’s Syndrome, a severe immune-mediated disease. This research is being done to investigate the safety and efficacy of the topical steroid, clobetasol 0.05% ointment, in the experimental treatment of toxic epidermal necrolysis/Stevens-Johnson’s Syndrome with topical steroids and to characterize the genetic makeup of the disease and its response to therapy.

Drug study, Phase [1, 2]
Any, age 7 to 85 years old

An Observational Study of Acute Burn Resuscitation (fluid infusion)

This is an observational study focusing on patients admitted to the burn center at UC Davis Medical Center.

This observational study will involve real-time data collection. It will focus on patients admitted to the burn center at UC Davis Medical Center. The team will study patients receiving fluid resuscitation during the first 48 hours after burn injury. Data collected will include fluid infusion rates, vital signs, and laboratory values. All procedures will follow UC Davis Medical Center's standard of care. Data on outcomes (organ function, ventilation duration, length of stay, and survival) will be collected at 72 hours, 96 hours, and at hospital discharge.

Observational Study
Any, age 18 years or older
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