UC Davis Health Clinical Studies

A Study of Snacks and Satiety (feeling fed)

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There are still many questions about how we control our appetite and overall food intake. One theory is that fluctuations in blood glucose tell the brain to eat or stop eating. Another theory suggests that certain amino acids in proteins we eat provide ‘stop’ and ‘go’ signals for eating. Many nutrition studies point to high protein or high carbohydrate foods to influence appetite. However, it is not clear if eating snacks, high or low in protein or carbohydrate, can actually affect appetite. We are doing this study to determine if snacks affect appetite and overall food intake. The snacks being used in this study are either almonds (higher in proteins) or a cereal blend (higher in carbohydrates).

Other study
Female, age 18 to 45 years old

A Study of Outpatient Cervical Preparation to Reduce Induction Duration in Pregnant Women

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This study is to compare 2 groups in nulliparous women undergoing cervical ripening for induction of labor. The study hypothesis is that outpatient cervical preparation with a foley catheter can reduce the induction of labor (IOL) time interval from admission to delivery by 50%. A 30 ml transcervical foley catheter is a safe mode of cervical preparation in the outpatient setting, as concluded in Diederen et al, Sciscinoe et al, and Kelly et al. Findings from studies on nulliparous, term, singleton vertex (NTSV) showed patients can be applied to a wide variety of maternity unit sizes as discussed by Main et al. No previous study has evaluated the effectiveness of outpatient cervical preparation in the NTSV population by PUBMED search. Further, no previous study has assessed patient satisfaction cervical preparation in the outpatient setting and no previous study has evaluated whether outpatient cervical preparation has an impact on the length of stay and cost of hospitalization. This study will explore these important questions with the goal of improving current practices in labor induction to be more patient-centered, pragmatic, and cost-effective.

Other study
Female, age 18 years or older

Need Emergency Contraception? Participate in a research study.

We want to find out which morning-after pill is most effective in women who weigh 176 pounds or more

This study aims to find out which morning-after pill is most effective in women weighing 176 pounds or more. If you had unprotected sexual intercourse and are looking for birth control options, consider participating. Emergency contraception, also “the morning-after pill" or "plan b”, can prevent pregnancy after unprotected sexual intercourse. Unprotected intercourse includes no contraceptive used, condom breakage, and other barrier contraceptive method failures. This clinical study happens at the UC Davis Department of Obstetrics and Gynecology. All participants will receive FDA-approved emergency contraception and specialty care at no cost. Compensation for your time is available.

Drug study, Phase 4
Female, age 18 to 40 years old

A Study of Mammographic Breast Density For Hormone Receptor-Negative Breast Cancer Enrolled on Study A011502

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This study is being done as a companion study to the Alliance A011502 clinical trial. The purpose of this study is to see if the use of aspirin causes a decrease in mammographic breast density. The breast is composed of fat, milk glands and various other tissues. These determine how dense the breasts are. High breast density has been shown to be a strong risk factor for developing breast cancer. It is thought that decreasing breast density may decrease the risk for breast cancer. The main goal of this study is to see whether women treated with aspirin will have reduced breast density as seen on a mammogram. Breast density is determined by a mammogram, and cannot be determined by a physical exam.

Procedure study
Female, age -1 years or older

A Study of Atezolizumab, Guadecitabine, and CDX-1401 For Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma

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This study will test the safety of the experimental combination of two drugs called SGI-110 and Atezolizumab. If this combination causes significant side effects, the dose of SGI-110 may be lowered for additional patients entering the study. Atezolizumab is not FDA approved for treating your type of cancer. SGI-110 is not approved by the FDA for any medical condition. Atezolizumab is a monoclonal antibody against PDL1 (a protein that allows tumor cells to escape the killing effect of T cells). SGI-110 is a drug that increases the effect of the genes that make tumor antigens on the surface of tumor cells. It also enhances the activity of tumor-killing T cells against those tumor cells.

Drug study, Phase [/1/,/ /2/]
Female, age 18 years or older
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