UC Davis Health Clinical Studies

A Registry Study for Pediatric Patients With Antiphospholipid Syndrome (the immune system wrongly attacks normal blood proteins)

This research study will take a look at Antiphospholipid Syndrome in order to learn how to better diagnose and control it.

This is a research study. Research studies only include people who choose to take part. You are being invited to join a research study because you have an auto immune / immunologic disease. You are being asked to take part in this study because you were seen at the Pediatric Nephrology Clinic at UC Davis Medical Center for a condition called Antiphospholid Syndrome. This condition may be caused by different diseases. We hope to learn more about how these diseases and conditions present. We hope to prepare you, your doctor, and others to better diagnose and control it. You will NOT receive any drug as part of this study, other than the ones that your health care provider feels are necessary as part of your routine care.

Any, age 0 to 18 years old

An Observational Study: 5-year Long-Term Study of Patients Undergoing Therapy for Inflammatory Bowel Disease

Researchers are collecting information on patients with inflammatory bowel disease (IBD). Help us learn how to better treat and manage it!

You are being asked to be in this research study because you have inflammatory bowel disease (IBD). This includes Crohn’s disease (CD), ulcerative colitis (UC), and Indeterminate Colitis (IBDU). These are chronic inflammatory disorders of the gastrointestinal (GI) tract. The goals of this study are to collect information on patients with IBD. We hope to determine the natural course of the disease and to determine how procedures or treatments may affect IBD and general health. This research study intends to observe any treatment for IBD in a “real life” setting. Researchers will observe how these treatments, lifestyle changes, and counseling work for patients. We will collect information about which treatments are being used and your response to these treatments. We hope this will help researchers better understand how to manage IBD. By doing this study, researchers hope to: • Find out more about patients who have IBD including their age, race/ethnicity, and other medical conditions they may have • Learn more about how often patients with IBD need to go to the hospital or have surgery • Learn about different medications, supplements and other treatments that are being used to manage IBD and how they may affect certain types of patients • Understand the effects of different durations, timing, sequences and medicines for IBD therapy in different groups of patients • Learn more about the different side effects of IBD treatment in the ‘real world’. For example, researchers hope to learn about the number of side effects, how side effects are treated, and the number or type of side effects that may cause patients to stop IBD treatment • Understand the different interactions between therapies used for IBD and other medicines patients may be taking • Better understand how different treatments affect what patients are able to do and how they feel • Learn about the long-term effects of IBD treatment on patients’ health • Create a “Biorepository Specimen Bank” with blood samples

Observational Study
Any, age 2 years or older

A Registry Study: Global Anticoagulant Registry for Venous Thromboembolic Events (blood clot in a vein)

We invite you to take part in a research study because you have recently been diagnosed with a blood clot in your leg or chest.

You are being invited to participate in this registry as you have been diagnosed with an Venous Thromboembolic Event (VTE). VTEs are events such as deep vein thrombosis (DVT) which is the occurrence of a clot in a deep vein (usually in the leg) or a pulmonary embolism (PE). This is when a blood clot or part of a clot travels to the lungs and causes a blockage. This registry is an observational study. This means that routine clinical practice is observed. Any treatment given follows the normal routine and is decided by you and your treating physician. This study will not alter or interfere with your care in any way.

Observational Study
Any, age 18 years or older

The Watch the Spot Trial

Help us find the best timing for CT scans to keep an eye on small lung nodules.

Each year, over 1 million Americans learn that they have a potentially cancerous lung nodule. These are usually found by chance on a chest x-ray or chest CT scan. Lung cancer screening is now recommended for high-risk smokers and former smokers. This helps detect lung nodules earlier, when it is more treatable. Cancerous nodules can be cured with surgery when promptly diagnosed and treated. Fewer than 5% of nodules prove to be cancerous. A key question is how to distinguish malignant nodules from benign ones. Small nodules measuring up to 15 mm are difficult to biopsy or remove. The default option for evaluation is a series of CT scans to identify growth that is suggestive of cancer. The best time-frame of surveillance has never been determined. This study will compare more intensive vs. less intensive surveillance in patients with small pulmonary nodule(s) on chest CT.

Other study
Any, age 35 years or older