UC Davis Health Clinical Studies

A Study of the Effects of Sweet Cherry Juice on Metabolism (converting food to energy) and Heart Health

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

This research study will test whether regular consumption of cherry juice improves cardiovascular (heart) and metabolic (converting food to energy) health. This study will involve: - daily consumption of study beverages, - tracking study beverage and food consumption in a food diary, - completion of 9 at-home dietary records, - one screening visit and 6 study visits. Here are some reasons you may not want to participate in this research: - You may find frequent test visits at the research center inconvenient and time consuming. - You may find it tedious to: -- drink study beverages, -- limit consumption of certain foods and beverages, -- complete dietary records and questionnaires. - You may find the following procedures uncomfortable: -- blood draws, -- the PAT procedure, -- continuous blood pressure monitoring (CNAP) -- MindWare electrode placement.

Dietary Supplement study
Any, age 20 to 65 years old

The Breast Cancer WEight Loss Study (BWEL Study)

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

This study is being done to see if losing weight may help prevent breast cancer from coming back. Studies have found that women who were overweight or obese women when diagnosed with breast cancer have a greater risk of their breast cancer recurring. This is compared to women who were thinner when their cancer was diagnosed. At this time we do not know whether losing weight will reduce the risk of breast cancer returning. This study will help to show us whether weight loss programs should be a part of breast cancer treatment.

Other study, Phase 3
Female, age 18 years or older

Koa Family: California's Obesity Prevention Project

This study hopes to learn if a new whole health program improves the health of low-income mothers.

The purpose of this study is to learn if a new whole health program improves the health of low-income mothers. To be eligible for this study, you must be a woman between the ages of 18 and 47. You must be comfortable speaking and reading English and be a mother (or caregiver) whose youngest child is between the ages of 3 and 17. You also must live in a low-income household (at or below 185% of the Federal Poverty Level), live in the Mack Road neighborhood of Sacramento or the City of Woodland, and have a cell phone that can receive text messages.

Behavioral study
Female, age 18 to 47 years old

The Effects of Sucrose-sweetened Beverage in African-American and Caucasian Women (SAAC) Study

In this study, we hope to learn about the metabolism of koolaid beverages that contain added sucrose (table sugar).

The main goal of this research study is to learn about the metabolism of koolaid beverages that contain added sucrose (table sugar). We hope that what we learn will help patients in the future. As with all research studies, no one can guarantee that participating in a research study will help you. We invite you to take part in a research study if you: - identify as either an African-American or non-hispanic White woman. - are a woman between the ages of 18-45 years. - are a nonsmoker who does not have diabetes mellitus or liver, kidney or thyroid disorders. - do not take hypolipidemic, anti-diabetic, anti-hypertensive or anti-depression medication. - have a stable body weight during the prior 6 months

Biological Study
Female, age 18-45

A Study of the Effect of Orange Juice or Sugar-Sweetened Beverages on Risk Factors for Type 2 Diabetes and Cardiovascular Disease

In this study, the study team will provide meals and either sugar-sweetened beverages or orange juice.

In this study, we hope to learn more about the effects of drinking sugar-sweetened beverages or orange juice. The beverages will be given with meals that we provide. Therefore, we will know exactly what the meals consists of. The study team will provide meals and either sugar-sweetened beverages or orange juice. We will compare the effects that the beverages have on blood triglyceride and cholesterol levels. We will look at your body’s reaction to insulin (hormone which lowers blood sugar).

Other study
Any, age 18 to 50 years old

A Study of Experimental Treatment With Micropulse for Diabetic Macular Edema (build-up of fluid in the eye)

This study will test the effect of using the subthreshold micropulse diode laser (SML).

Diabetic macular edema (DME) is the term used for swelling in the central part of the retina. The retina is the light-sensitive tissue lining the back of the eye and is responsible for sharp, straight-ahead vision. The retina is nourished by blood vessels. These blood vessels can become weakened by diabetes. This causes the retina to become thickened or swollen. Swelling of the central part of the retina can cause vision loss. Some common treatment strategies for vision loss due to diabetic macular edema are: - laser treatment - intra-ocular injections with medications such as corticosteroids - anti-vascular endothelial growth factor (anti-VEGF) The purpose of this study is to test the effect of early treatment using the subthreshold micropulse diode laser (SML). This is a laser treatment that delivers laser energy in a “chopped” fashion allowing the tissue being treated to cool between pulses. Previous studies have shown that early intervention with SML may significantly improve or stabilize vision loss.

Device study
Any, age 18 years or older

Testing the Impact of Biotin Supplements (vitamin that helps convert food into energy) on Thyroid Stimulating Hormone Test Results

This study hopes to determine if biotin (a vitamin found in dietary supplements) can interfere with a new assay.

Thyroid stimulating hormone (TSH) testing may be affected by biotin. Biotin is a water soluble B-vitamin often recommended as a dietary supplement. It can be found in a variety of other health products found on the market. Certain TSH assays may be affected by biotin and show falsely low results at certain levels of biotin. This study hopes to determine if biotin can interfere with a new assay. An assay is a blood test that looks for the presence of a substance and the amount of that substance. This assay has recently been approved by the FDA. We will compare the results with results from two different FDA approved assays that have no known interference from biotin.

Observational Study
Any, age 18 years of age and older

Metabolic Effects of Sugar and Aspartame

What are the effects of consuming sugar- and aspartame-sweetened beverages with standardized diets?

We hope to learn more about the effects of consuming sugar- and aspartame-sweetened beverages with meals in a situation in which we know exactly what the other meal components consists of. Therefore, throughout the first 6 weeks of the study we will provide the participants with the sweetened beverages and the meals that they will consume with the beverages. This will allow us to study if consumption of sugar-sweetened beverages has effects on your blood triglyceride and cholesterol concentrations and your body’s sensitivity to the hormone insulin without having to account for the other components in your usual diet. We also hope to learn more about the effects of consuming sugar-sweetened beverages with the meals people usually consume. Therefore during the last 4 weeks of the study participants will consume the beverages we provide with their normal meals.

Other study
Any, age 18 to 40 years old
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