UC Davis Health Clinical Studies

A Study of Museum-Based Experiences to Reduce Social Isolation and Pain

Can participating in museum programs help individuals with chronic pain feel more socially connected? Help us find out!

This research study will develop and evaluate museum-based programs. These programs will aim to address loneliness and social isolation among individuals with chronic pain. Over 100 million American adults suffer from chronic pain. This is more than those with heart disease, cancer, and diabetes combined. Chronic pain is complex. It affects the body, the mind, and social interactions. Previous studies show that social disconnection can cause pain to feel more intense. Studies also show that social connection can help decrease the intensity of pain. Museums may be able to reduce isolation and give people a sense of social connection. We hope to learn if museum engagement in individuals with chronic pain can decrease feelings of social disconnection and the unpleasantness of chronic pain.

Other Study
Any, age 18+

A Study of the Safety and Effectiveness of Experimental RO7234292 for Huntington's Disease

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The purpose of this study is to compare the effects of experimetnal RO7234292 in study participants with Huntington’s Disease (HD). RO7234292 is an experimental drug, which means the FDA has not approved RO7234292 for the treatment of HD or any other condition. HD is a rare progressive neurological disease. It affects thought processes, movement, personality, and/or mood. Huntington’s Disease (HD) is caused by the production of a toxic protein within cells. RO7234292 (Study Drug) has been shown to lower levels of this protein in the first clinical trial by interfering with its production. It is hoped that reducing the production of this protein, progression of disease can be slowed or stopped. This study aims to test this idea.

Drug study, Phase 3
Any, age 25 to 65 years old

A Study Evaluating Behavioral Intervention in those at risk for Alzheimer’s Dementia

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Older adults with memory changes may eventually experience difficulty with activities of daily living (such as managing finances). This study will test an intervention for older adults who are experiencing concerns with thinking ability but do not have difficulty with managing activities of daily living. The goal of this intervention is to increase skills using a calendar system, goal setting and task list system, and organizational strategies. This intervention encourages engagement in healthy lifestyle activities such as physical exercise, intellectual stimulation, and positive emotional functioning to further promote brain health. Participants may have increased engagement in brain health activities and improved compensation strategies. All participants will have a chance to complete the intervention.

Behavioral study
Any, age 65 years or older

The Staged Treatment in Early Psychosis Study

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This study will investigate the most effective way of treating young people at risk of developing a psychotic disorder. We do not yet know what the most effective type of treatment is or the best sequence of treatments. We would like to test the effect of a sequential treatment approach for at-risk young people. This means giving them a sequence of three treatments, depending on whether the young people have a good response to each stage of treatment. The study will measure whether or not the treatment sequence was effective by: -whether the treatments improved functioning levels and psychiatric symptoms -whether or not they prevent or delay some young people transitioning to psychosis -whether they help diminish some young people’s at-risk status. The results of this study will assist with providing the best possible care in the future for young people who may be at risk of developing a psychotic disorder. It may also help us understand why some people’s symptoms and functioning get worse over time and why other people’s improve. Medications, drugs and devices have to be approved for use by the FDA. Fluoxetine is approved by the US Food and Drug Administration to treat depression. However, it is not approved to treat risk for psychosis. Therefore, its use in this study is considered to be experimental. This study will help determine if fluoxetine is an effective treatment for risk for psychosis. The research has been initiated by the study doctor, Cameron Carter, and is funded by a research grant from the US National Institute of Health (NIH).

Behavioral study, Phase 3
Any, age 12 to 25 years old

HIV Post-Exposure Prophylaxis Uptake and Adherence Post-Sexual Assault

Looking for men and women who have been offered medications to prevent HIV following sexual assault

Thank you for your interest in taking part in the My Experiences Navigating Daily-life (MEND) research study. The purpose of this study is to get information about how and why people do or do not take HIV post-exposure prophylaxis (PEP) (medications to prevent HIV) in the four weeks after a sexual assault. Your participation will involve taking a survey via an internet-based web-application. Completing this survey means you consent to participate in this study. There are two parts to the survey: a screening section and the main survey. After finishing the screening section, you may or may not be selected to complete the main survey. The main survey will take about 30-45 minutes to complete. You can complete the survey two ways: (1) anonymously, or (2) you may choose to provide your email address to receive a gift card for your time.

Online survey
Any, age 18+