UC Davis Health Clinical Studies

Effects of Brain Stimulation on Cognition, Oscillations and GABA Levels in Schizophrenia

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The purpose of this research study is to learn more about how the brain functions during cognition. We hope to learn whether stimulating an area of the brain called the prefrontal cortex can improve these processes. We are doing this research to: - understand how the brain functions during these processes - understand how it responds to stimulation, - provide important new scientific information We hope this study will answer questions relevant to mental health disorders including schizophrenia. Our goal is that it could eventually lead to the development of new treatments.

Device study
Any, age 18 to 35 years old

The Digital Memory Notebook: Training to Improve Everyday Functioning in Older Adults with Mild Cognitive Impairment

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We invite you to take part in a research study because you are an adult over the age of 60. We invite individuals with personal concerns regarding: -memory -thinking abilities and/or -mild difficulties with thinking and remembering. The purpose of this study is to train older adults who are at risk for memory and thinking problems. We will train then to use a tablet-based application (app) . The app is called the Digital Memory Notebook (DMN) to support everyday functioning and independence.

Behavioral study
Any, age 60 years or older

A Study of Virtual Museum-Based Experiences to Reduce Social Isolation and Pain

Can participating in virtual museum programs help individuals with chronic pain feel more socially connected? Help us find out!

This research study will develop and evaluate virtual museum-based programs. These programs will aim to address loneliness and social isolation among individuals with chronic pain. Over 100 million American adults suffer from chronic pain. This is more than those with heart disease, cancer, and diabetes combined. Chronic pain is complex. It affects the body, the mind, and social interactions. Previous studies show that social disconnection can cause pain to feel more intense. Studies also show that social connection can help decrease the intensity of pain. Museums may be able to reduce isolation and give people a sense of social connection. We hope to learn if virtual museum engagement in individuals with chronic pain can decrease feelings of social disconnection and the unpleasantness of chronic pain.

Other Study
Any, age 18+

A Study Evaluating Behavioral Intervention in those at risk for Alzheimer’s Dementia

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Older adults with memory changes may eventually experience difficulty with activities of daily living (such as managing finances). This study will test an intervention for older adults who are experiencing concerns with thinking ability but do not have difficulty with managing activities of daily living. The goal of this intervention is to increase skills using a calendar system, goal setting and task list system, and organizational strategies. This intervention encourages engagement in healthy lifestyle activities such as physical exercise, intellectual stimulation, and positive emotional functioning to further promote brain health. Participants may have increased engagement in brain health activities and improved compensation strategies. All participants will have a chance to complete the intervention.

Behavioral study
Any, age 65 years or older

The Staged Treatment in Early Psychosis Study

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This study will investigate the most effective way of treating young people at risk of developing a psychotic disorder. We do not yet know what the most effective type of treatment is or the best sequence of treatments. We would like to test the effect of a sequential treatment approach for at-risk young people. This means giving them a sequence of three treatments, depending on whether the young people have a good response to each stage of treatment. The study will measure whether or not the treatment sequence was effective by: -whether the treatments improved functioning levels and psychiatric symptoms -whether or not they prevent or delay some young people transitioning to psychosis -whether they help diminish some young people’s at-risk status. The results of this study will assist with providing the best possible care in the future for young people who may be at risk of developing a psychotic disorder. It may also help us understand why some people’s symptoms and functioning get worse over time and why other people’s improve. Medications, drugs and devices have to be approved for use by the FDA. Fluoxetine is approved by the US Food and Drug Administration to treat depression. However, it is not approved to treat risk for psychosis. Therefore, its use in this study is considered to be experimental. This study will help determine if fluoxetine is an effective treatment for risk for psychosis. The research has been initiated by the study doctor, Cameron Carter, and is funded by a research grant from the US National Institute of Health (NIH).

Behavioral study, Phase 3
Any, age 12 to 25 years old