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UC Davis Health Clinical Studies

A Study of Experimental Radiation Therapy With Cisplatin or Cetuximab for Oropharyngeal Cancer

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Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells. They either kill the cells or stop them from dividing. Monoclonal antibodies, such as experimental cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether radiation therapy is more effective with cisplatin or cetuximab in treating oropharyngeal cancer. This study will test radiation therapy with cisplatin or cetuximab. We hope to see how well it works in treating patients with oropharyngeal cancer.

Biological study, Phase 3
Any, age 18 to 120 years old

A Study of Radiation Therapy With Experimental Durvalumab or Cetuximab For Head and Neck Cancer Who Cannot Take Cisplatin

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This study will test the effects of radiation plus the experimental study treatment, MEDI4736 (durvalumab). It will be compared to the usual therapy of radiation plus cetuximab. The study is for patients with head and neck cancer who cannot take the drug cisplatin. MEDI4736 works by boosting your immune system to help recognize and fight cancer. MEDI4736 is FDA-approved for cancer of the urinary system. It is not approved for use with radiation therapy in head and neck cancer. The study treatment may or may not shrink your cancer, but it could also cause side effects. This study will allow the researchers to know whether this different approach (radiation and MEDI4736) is better, the same, or worse than the usual approach.

Biological study, Phase [/2/,/ /3/]
Any, age 18 years or older

A Study of Experimental Individualized Chemotherapy Treatment for Nasopharyngeal Cancer Based on Epstein Barr Virus DNA

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You are being asked to take part in this study because you have nasopharyngeal cancer (in the head and neck region of your body). Your cancer has not spread to other parts of your body. People who are not in a study are usually treated with radiation and chemotherapy, followed by more chemotherapy. There are several FDA-approved chemotherapy drugs that are commonly used as part of this treatment. For patients who receive the usual approach for this cancer, on average 70 patients out of 100 are free of cancer at five years. This study is being done to see how people with your type of cancer respond to different chemotherapies, based on a specific viral marker in their blood. This viral marker is called the Epstein Barr virus, (EBV). A more individualized approach to treating your type of cancer might be found using this blood marker.

Drug study, Phase 2/3
Any, age 18 years or older

Comparison of Radiation Therapy and Chemotherapy Combinations for Treatment of Oral Cancer

You are invited to be a part of this study if you have Stage III or IV Oral Cancer.

You are invited to be a part of this study if you have Stage III or IV Oral Cancer. The purpose this study is to find out the good and/or bad effects of the following treatments on you and your cancer. In this study, you will receive one of the following treatments: • Standard treatment: radiation therapy and Cisplatin • Experimental treatment: radiation therapy and Docetaxel • Experimental treatment: radiation therapy, Docetaxel, and Cetuximab Cisplatin and Docetaxel are standard chemotherapy drugs for your type of cancer. The dose and treatment schedule of Docetaxel given in this study is experimental. Cetuximab is a drug that blocks the epidermal growth factor. Epidermal growth factor is a protein that affects cancer growth and many other functions.

Drug study, Phase [/2/,/ /3/]
Any, age 18 years or older

A Randomized Phase II Study of Adjuvant Concurrent Radiation and Chemotherapy Versus Radiation Alone in Resected High-Risk Mali...

If you have salivary gland cancer that is at-risk to return after surgery, this study will test treatment with chemotherapy and radiation.

You are being asked to take part in this study because you have cancer of the salivary gland. Your cancer is at high risk to come back after surgery. The standard treatment for cancer of the salivary gland is surgery. All patients will have had surgery before taking part in this study. Although the surgery may have removed your cancer, features of your disease suggest that you are at an increased risk for your cancer to return. Patients at risk for disease return after surgery usually receive radiation therapy to the head and neck after surgery. The purpose of this study is to test the use of chemotherapy with radiation. The study team wants to know if combining this treatment is better than radiation alone. The study will compare the good and bad effects on you and your salivary gland cancer. We want to know which is better at reducing the chance that your cancer will come back.

Drug study, Phase 2
Any, age 18 to 80 years old

A Study of Continuous Positive Airway Pressure (CPAP) to Improve Swallow Function After Total Laryngectomy

A Continuous Positive Airway Pressure (CPAP) machine can improve swallow function if you've had a total Laryngectomy.

This research will determine whether the use of Continuous Positive Airway Pressure (CPAP) can improve swallowing in patients who underwent total laryngectomy and are experiencing difficulty swallowing. Total laryngectomy removes the larynx and separation of the airway from the mouth, nose and esophagus. In normal individuals, CPAP machine delivers enough air pressure to keep upper airway passages open. Since your airway is separated from your mouth and esophagus, the mask will apply pressure on your mouth and esophagus during swallowing.

Device study
Any, age 18 years or older

Study looking at safety and efficacy of the Swallow Expansion Device (SED) for improvement of severe swallowing issues

Can the Swallow Expansion Device (SED) treat severe dysphagia?

Biomedical devices, such as artificial joints and pacemakers, are accepted and commonly used in medicine, however, there is currently no device available to assist with the act of swallowing. We have developed a biomedical device (Swallow Expansion Device, SED) that assists with swallowing by mechanically opening the upper esophageal sphincter and allowing food and liquid to safely enter the esophagus. This study is looking at the safety and efficiency of the SED as treatment for severe dysphagia.

Device study
Any, age 18 to 100 years old

Study comparing one dose pre-surgery oral or IV Acetaminophen for pain control in Tonsil and Adenoid Removal

Does Acetaminophen (Tylenol) given before surgery, lessen need for opioids/narcotics?

The purpose of the study is to compare pain control between two forms of acetaminophen, and to possibly save money for future patients who have to undergo the same surgery as your child. Acetaminophen, otherwise known as Tylenol or Ofirmev, has been used by medical providers to help treat moderate to severe surgical pain in children. It is used with various medications including opioids or narcotics to treat pain after surgery. Opioids/narcotics are strong morphine-like medicines that can have multiple side effects that can be very serious in children after tonsillectomies and adenoidectomies (for example: slower breathing rates, sedation, and obstruction). Because of this, there is interest in the use of acetaminophen to manage surgical pain. Other studies have shown that if acetaminophen is given to a child, then the child will need less of these stronger pain medications to be comfortable after surgery. Acetaminophen comes in various forms including an inexpensive oral form (Tylenol) and a more expensive intravenous (IV) form (Ofirmev). We think that one loading oral dose of acetaminophen given before surgery can provide better pain control (as measured by less need for morphine-like medicine) compared to one dose of intravenous acetaminophen for pediatric tonsillectomy and adenoidectomy patients

Drug study, Phase 4
Any, age 4 to 17 years old