UC Davis Health Clinical Studies

Testing the Safety and Effectiveness of Experimental Sarilumab in Hospitalized Patients With COVID-19 (Coronavirus)

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

You are being asked to take part in a research study because you have the COVID‑19 virus. This study will test the safety and effectiveness of the experimental drug, sarilumab (study drug). This study is sponsored by Regeneron Pharmaceuticals, Inc. (“Regeneron”). Sarilumab (also known as Kevzara®) is considered an experimental drug in this study. It has not been approved by the FDA for the condition being studied. However, it has been approved in multiple countries for active rheumatoid arthritis. Sarilumab is a type of drug called a “monoclonal antibody”. An antibody is a special kind of protein that your immune (defense) system normally makes to fight bacteria and viruses. Scientists can now make antibodies in the laboratory for the treatment of many different diseases. Sarilumab has been specifically shown to block the action of a protein called interleukin-6 (IL-6) in your body. Interleukin-6 (IL-6) is a protein in the immune system that has been shown to play an important role in inflammation. Inflammation may be associated with symptoms and complications of COVID‑19. The main purpose of this study is to determine if sarilumab is safe and if it can decrease the amount of time you have COVID-19 symptoms.

Drug study, Phase 2/3
Any, age 18 years or older

Experimental Treatment with Remdesivir for Patients Hospitalized With Coronavirus Infection (COVID-19)

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

There are no approved medications to treat COVID-19 because it is a new disease caused by a virus that was just identified in 2019 in China. Some people who become sick with COVID-19 have serious disease and must be hospitalized. This study will test a drug in adult patients that are hospitalized with COVID-19. The drug has been tested before in humans with other diseases. In this study, we would like to make sure that it is safe for use in humans with COVID-19 and see if it can improve patients’ health when they are sick with COVID-19. We are studying the experimental use of a drug called remdesivir. This drug has been studied in animals and in people. It is given as an infusion, which means that it is given through a plastic tube attached to a needle that is put into a vein in the arm. To find out if remdesivir (the study drug) works, we need to compare it to getting something that does not have the drug in it, something called a placebo. The placebo looks like the study drug but does not have the drug in it. Using a placebo is common in research studies. The placebo is also given as an infusion. Some people in the study will get the placebo.

Other study, Phase 2
Any, age 18 to 99 years old

A Study of the Safety and Activity of Experimental GS-6207 Injection for HIV-1 Infected Adults

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

The purpose of this study is to test the experimental medicine GS-6207 (referred to as study drug). We hope to determine how it affects the HIV infection in your body and how long the study drug stays in your body. The safety and how well the study drug is tolerated will also be determined by using: - physical exams, - laboratory tests, and - any symptoms or problems you might experience during the study.

Drug study, Phase 1
Any, age 18 to 65 years old

A Study Testing the Long-term Safety and Effectiveness of Experimental VX-445 Combination Therapy in Cystic Fibrosis

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

This study is being done to learn more about the effectiveness and safety of an experimental combination of medicines. The combination of VX-445/tezacaftor (TEZ)/ivacaftor (IVA) will be tested in patients with cystic fibrosis. • The triple combination VX-445/TEZ/IVA is an experimental drug. This means the study drug is not approved by the FDA. It is still being tested for safety and effectiveness. • TEZ in combination with IVA (TEZ/IVA) is approved in certain countries for use in some people living with CF who are 12 years or older. • IVA is approved in a number of countries globally, for use in some people living with CF who are as young as 6 months, depending on the country. If you would like to know in which countries or for which people living with CF TEZ/IVA or IVA has been approved, please ask your Study Doctor.

Drug study, Phase 3
Any, age 12 years or older

A Study of Experimental VX-445 Combination Therapy for Cystic Fibrosis with Genetic Mutations (F508del and Gating or Residual)

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

This study will test the effectiveness and safety of the experimental medicine VX-445. It will be combined with TEZ and IVA in subjects with cystic fibrosis (CF). • The triple combination VX-445/TEZ/IVA is an experimental drug. This means the Study Drug is not approved by the FDA and is still being tested for safety and effectiveness. • TEZ combined with IVA (TEZ/IVA) is approved in some countries for use in some people living with CF who are 12 years or older. • IVA, the third Study Drug used in this study, is approved in a number of countries globally. It is used for people living with CF who are as young as 6 months, depending on the country. • Please ask the Study Doctor if you would like to know in which countries or for which people living with CF TEZ/IVA or IVA has been approved.

Drug study, Phase 3
Any, age 12 years or older

Study of Experimental Sulbactam-ETX2514 Infections Caused by Acinetobacter baumannii-calcoaceticus Complex

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

We are doing this study to test the effectiveness and safety of the experimental drug sulbactam-ETX2514. It is being tested for the treatment of infections caused by A. baumannii bacteria. This type of infection is usually resistant to many existing drugs. New drugs are needed to effectively fight A. baumannii bacteria. The study drug is not approved for the treatment of infections due to A. baumannii. The study drug itself is made up of two chemicals, one is called ETX2514, an investigational antibiotic. The other chemical that makes up the study drug is called sulbactam, an FDA-approved antibiotic. The combination that is this study drug is called “ETX2514SUL.”

Drug study, Phase 3
Any, age 18 years or older

A Study of Experimental Therapy With Nivolumab For Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Disease

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

This study is being done to answer the following question: Can we safely and effectively treat your cancer with nivolumab given any of the following auto-immune diseases? -Rheumatoid arthritis -Polymyalgia rheumatica -Sjogrens -Ulcerative colitis -Crohn's disease -Systemic lupus erythroderma -Dermatomyositis -Multiple sclerosis Nivolumab is an antibody that can block signals that some types of tumors may use to suppress the immune system. We are doing this study because we want to find out if this approach is better or worse than the usual approach for your cancer and your auto-immune disease. The usual approach is defined as care most people get for their cancer while having an auto-immune disease. Treatment with nivolumab is considered experimental. It is not currently approved by the FDA for cancer in people with auto-immune diseases.

Drug study, Phase 1
Any, age 18 years or older

A Study of the Safety and Effectiveness of Experimental Lonafarnib / Ritonavir for Chronic Hepatitis D Virus Infection

Volunteer for research at UC Davis and contribute to discoveries that may improve health care for you, your family, and your community!

This study is for patients with chronic (long-lasting) hepatitis D virus (HDV) infection. Potential participants must be taking or be willing to begin taking nucleotide/nucleoside inhibitors (entecavir or tenofovir). These nucleotide/nucleoside inhibitors must be taken for at least 12 weeks to 6 months before beginning the study treatment. The purpose of this study is to determine whether the study drugs will reduce the amount of HDV in your blood. Other purposes of this study are: - to determine the effects of the study drugs on your liver - to determine if taking the study drugs makes your quality of life better - to evaluate the safety of the study drugs The Sponsor is conducting this study to find new treatments for HDV. This research study is designed to learn more about an investigational drug called lonafarnib. It is being developed to treat chronic HDV infection as well as other conditions. "Investigational" means lonafarnib is not yet approved by the FDA for prescription or over the-counter (OTC) use. Lonafarnib will be taken in combination with an approved drug called ritonavir. Ritonavir is commonly used in the treatment of hepatitis C at comparable dosing to what will be used in this study. In this study, ritonavir is used as a “booster” to increase the amount of lonafarnib in your body. A “booster” is a drug that prevents your body from breaking down lonafarnib, so it can work longer. Some patients in this study will take an interferon medicine approved for treating HBV and hepatitis C virus (HCV) infections. This medicine is called peginterferon-alfa-2a (abbreviated as PEG IFN-alfa-2a). PEG IFN-alfa-2a will be a potential added medicine in this study. We hope to determine if it improves the treatment outcome when taken with lonafarnib and ritonavir. Peginterferon-alfa-2a is a solution that is injected under the skin once per week.

Drug study, Phase 3
Any, age 18 years or older
Loading