UC Davis Health Clinical Studies

Experimental Pembrolizumab Alone or Combined With Pemetrexed and Carboplatin For Advanced Non-Small Cell Lung Cancer (NSCLC)

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This study is being done to answer the following questions: Does immunotherapy with MK-3475 (pembrolizumab) alone improve overall survival? This will be compared to combination therapy with chemotherapy, in patients with your type of cancer. Does additional treatment with chemotherapy following immunotherapy alone also improve overall survival? We are doing this study because we want to compare these two usual approaches to cancer treatment. The usual approach is defined as care most people get for PD-L1 positive non-squamous non-small cell lung cancer.

Drug study, Phase 3
Any, age 18 years or older

A Study of Experimental Accelerated vs Standard Chemotherapy for Germ Cell Tumors (formed from reproductive cells)

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Standard treatment for advanced germ cell tumors includes three chemotherapy drugs. This is called BEP (Bleomycin, Etoposide, and cisPlatin). BEP is given with a drug called pegfilgrastim or filgrastim. This makes white blood cells grow. These drugs are given over the course of 3 weeks. This study will compare the standard chemotherapy regimen with an accelerated chemotherapy regimen. It will use the same drugs to see if the accelerated chemotherapy regimen is beneficial but not more toxic than the standard chemotherapy regimen. The accelerated chemotherapy is experimental. This method works by giving the dose of chemotherapy drugs over a shorter length of time. Instead of the standard 3 week-cycle, patients would receive their treatment in a 2 week-cycle. The overall goal of this study is to determine whether accelerated BEP will be effective and well-tolerated for patients with advanced GCTs. We don’t yet know if accelerated treatment is helpful in advanced GCTs and we are hoping this study will answer that question.

Drug study, Phase 3
Any, age 11 to 45 years old

A Study of an Experimental Combination Therapy of Radiation With or Without Cisplatin for Recurrent Endometrial Cancer

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The purpose of this research is to compare two different treatments for endometrial cancer: - radiation therapy combined with weekly treatment with the chemotherapy drug cisplatin and - radiation therapy alone. You are invited to be in this study because you have endometrial cancer that has come back (recurred) after surgery and chemotherapy. Your cancer does not appear to have spread beyond your pelvis.

Radiation study, Phase 2
Female, age -1 years or older

The PROSpect Study: A Pediatric Study to Test the Best Breathing Position for Children When They Are Sick

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This study is being done to learn the best way to help children breathe when they are sick. When children’s lungs are very sick they are on a machine to help them breathe. There are different types of breathing machines that can be used. The two types are usual or high frequency: 1) A usual breathing machine imitates a person’s normal breathing. 2) A high frequency breathing machine delivers fast and shallow breaths. There are also different positions a child can be in while on a breathing machine: 1) Lying on their back with a slight change in position every two hours. 2) Lying on their stomach for at least 16 hours each day with a slight change in position every 2 hours. When needed for medical care, your child will be turned on their back, and then returned to lying on his or her stomach. At UC Davis, we use both types of breathing machines and place children in both positions. The main purpose of this study is to find out if one approach is better than others in reducing the number of days a child spends on a breathing machine. The length of time your child spends on the breathing machine may be shorter or longer from taking part in this study.

Other study
Any, age -1 to 18 years old

A Study of of Museum-Based Experiences to Reduce Social Isolation and Pain

Can participating in museum programs help individuals with chronic pain feel more socially connected? Help us find out!

This research study will develop and evaluate museum-based programs. These programs will aim to address loneliness and social isolation among individuals with chronic pain. Over 100 million American adults suffer from chronic pain. This is more than those with heart disease, cancer, and diabetes combined. Chronic pain is complex. It affects the body, the mind, and social interactions. Previous studies show that social disconnection can cause pain to feel more intense. Studies also show that social connection can help decrease the intensity of pain. Museums may be able to reduce isolation and give people a sense of social connection. We hope to learn if museum engagement in individuals with chronic pain can decrease feelings of social disconnection and the unpleasantness of chronic pain.

Other Study
Any, age 18+

A Study of the Effect of an Oral Vaccine on the Digestive System

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The purpose of this study is to: 1. Determine whether ingesting the standard, 4-doses of a live, weakened typhoid fever vaccine will cause a temporary leaky gut and inflammation. Leaky gut is a condition when the gut lining becomes more permeable, or “leaky”, for substances in the gut to pass through to the tissues beneath it. 2. Compare the gut leakiness caused by this vaccine to the gut leakiness caused by a short-term ingestion of aspirin. 3. Examine whether the size of the body’s natural immune response to this vaccine is associated with gut leakiness and inflammation of similar size.

Biological study, Phase 1
Female, age 18 to 49 years old

Online Developmental Screening Study

Have you had a new baby? Learn about your baby's development!

Researchers at the UC Davis MIND Institute on the UC Davis Medical Center campus in Sacramento are conducting an online study tracking the development of infants from 6 to 36 months of age. The goal of the study is to help parents understand their child’s development and gain access to resources when needed. This study tests new online methods of tracking developmental milestones in babies. The UC Davis MIND Institute is a collaborative international research center, committed to the awareness, understanding, prevention and care of neurodevelopmental disorders.

Longitudinal screening study
Any, age 6 months
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