UC Davis Veterinary Clinical Trials

Circulating DNA in cats with hypertrophic cardiomyopathy and cardiogenic arterial thromboembolism

Help us look for a screening test to prevent clot formation in cats

Hypertrophic cardiomyopathy (HCM) is the most common heart disease in cats. About 20% of cats will develop clinical signs due to HCM. Of these complications, the most devastating is cardiogenic arterial thromboembolism (clot formation), otherwise known as, “saddle thrombus”, which is one of the most distressing emergencies for cat owners. This disease is complicated by the fact that most cats that develop saddle thrombus appear healthy and do not have heart murmurs. Veterinarians currently have limited abilities to test and treat cats at the greatest risk of forming saddle thrombus. For this reason, we hope to look for protein markers and free circulating DNA in the blood of cats with HCM and saddle thrombus. Free circulating DNA has been shown in humans, mice and dogs to promote clot formation and can be used as a treatment target. We, therefore, hope to further understand these findings by seeing if free circulating DNA in cats contribute to saddle thrombus in cats with HCM. This information will enable us to establish a screening test that will guide clinicians in identifying cats at risk of clot formation.

Any, age > 1 year old

Pituitary surgery for cats with pituitary tumors

Help us treat pituitary tumors in cats using surgery!

Cats with a brain tumor in their pituitary gland may produce too many hormones, causing a disease syndrome called feline hypersomatotropism (HS). It affects many organs including heart, kidneys, bone, and cartilage to name a few. Cats that suffer from hypersomatotropism will develop diabetes that is challenging to manage. One of the current treatments for feline HS is surgical removal of the pituitary gland. The purpose of this study is to find out the benefits of using BrainSight® neuronavigation system and Stortz® VITOM 3D endoscope to remove pituitary tumors in cats.

Device / Surgical Technique

Using stem cells to help cats with gingivostomatitis after having received a full dental extraction

Help us treat cats with gingivostomatitis!

Feline chronic gingivostomatitis (FCGS) is a painful disease in cats that needs medical or surgical treatments. A stem cell therapy where stem cells are taken from fat tissue is a new potential therapy for chronic inflammatory diseases. This cell therapy MAY help to correct abnormalities that may be involved with stomatitis in cats. Moreover, stem cells may help in regenerating damaged tissues. In this study, we will evaluate the effectiveness of using stem cells to treat cats with gingivostomatitis that have had full or near-full mouth extractions.

Stem Cell Study