UC Davis Veterinary Clinical Trials

Pituitary surgery for cats with pituitary tumors

Help us treat pituitary tumors in cats using surgery!

Cats with a brain tumor in their pituitary gland may produce too many hormones, causing a disease syndrome called feline hypersomatotropism (HS). It affects many organs including heart, kidneys, bone, and cartilage to name a few. Cats that suffer from hypersomatotropism will develop diabetes that is challenging to manage. One of the current treatments for feline HS is surgical removal of the pituitary gland. The purpose of this study is to find out the benefits of using BrainSight® neuronavigation system and Stortz® VITOM 3D endoscope to remove pituitary tumors in cats.

Device / Surgical Technique

Using stem cells to help cats with gingivostomatitis after having received a full dental extraction

Help us treat cats with gingivostomatitis!

Feline chronic gingivostomatitis (FCGS) is a painful disease in cats that needs medical or surgical treatments. A stem cell therapy where stem cells are taken from fat tissue is a new potential therapy for chronic inflammatory diseases. This cell therapy MAY help to correct abnormalities that may be involved with stomatitis in cats. Moreover, stem cells may help in regenerating damaged tissues. In this study, we will evaluate the effectiveness of using stem cells to treat cats with gingivostomatitis that have had full or near-full mouth extractions.

Stem Cell Study

Understanding how a cat's body processes the chemotherapy drug, chlorambucil

Help us find out how a cat's body processes chemotherapy drugs.

Small cell GI lymphoma is commonly diagnosed in older cats and recommended treatment of this cancer is an oral chemotherapy drug called chlorambucil in combination with prednisolone or prednisone. Despite the wide use of chlorambucil in cats, the pharmacokinetic parameters (i.e. how the body absorbs, metabolizes and eliminates the drug) have not been previously studied in cats. Knowledge of the pharmacokinetic parameters of chlorambucil in this population of older, cancer-bearing cats is critical to understand why some cats experience side effects with chlorambucil therapy and determine if variability in the metabolism of chlorambucil contributes to treatment failure.

Any, age None specified