UC Davis Veterinary Clinical Trials

Understanding the genetics causing ocular squamous cell carcinoma in horses

Help us find out what genes cause ocular squamous cell carcinoma in horses!

Squamous cell carcinoma (SCC) is one of the most common forms of cancer to affect the eye in horses, frequently occurring at the limbus, where the clear cornea meets the white of the eye, or on the nictitating membrane, also known as the third eyelid. This type of eye cancer affects some breeds more than others (e.g., Haflingers) so the objective of this study is to determine the role genetics plays in ocular squamous cell carcinoma in multiple breeds. This study is designed to determine the incidence of SCC, to determine the modes of inheritance and identify DNA variants that put horses at risk for this cancer.

Genetic Study

Understanding the genetics causing equine recurrent uveitis in horses

Help us understand why horses get recurrent uveitis!

Equine recurrent uveitis (ERU) is the leading cause of blindness in horses, marked by repeated episodes of inflammation of the uveal tract of the eye. Appaloosa horses, known best for their white coat spotting patterns (termed leopard complex or LP), are eight times more likely than any other breed to develop this disease and four times more likely to go blind, suggesting genetics plays a major contributing role. However, little is known about the specific genetic factors involved. The objective of this study is to determine the genetic factors contributing to ERU in multiple horse breeds.

Genetic study

Comparing How Stem Cells are Given to Horses with Laminitis

Help us understand more about stem cell therapy administration to horses with laminitis!

Degenerative disorders of the equine foot, such as laminitis are a major cause of foot lameness in horses. Unfortunately, laminitis is not only a devastating and expensive disease to treat, but there is also no true cure for the disease. Stem cell therapy is currently being examined at as a potential treatment for laminitis based on the ability of stem cells to replicate themselves, regenerate tissue, and repair damaged tissue. The purpose of this study is to assess the best administration method for mesenchymal stem cells (MSCs). The clinical use of stem cells is still in its early stages, and determination of the ideal route to administer these cells in horses affected by laminitis is worth further investigation.

Stem Cell Study

Assessing a Stem Cell Therapy for Intra-articular Lesions in Horses

Help us find a treatment for intra-articular lesions in horses using stem cells!

Intra articular disorders in horses remain as a major source of lameness and decrease performance. Conventional treatments are often long and expensive with less than optimal results and failure to return to a previous level of performance in the majority of cases. When intra articular lesions heal, scar tissue cannot be as functional as the original tissues, therefore the development of methods for regenerating tissue is our goal for an efficacious treatment. The purpose of this study is to assess stem cell therapy as a potential treatment for intra-articular lesions. The clinical use of stem cells is still in its early stages, and determination of the ideal dose to administer these cells is worth further investigation.

Stem Cell Study

Assessing a Stem Cell Therapy for Tendonitis and Desmitis in Horses

Help us find a treatment for tendonitis and desmitis in horses using stem cells!

Tendon and ligament injuries are a common cause of lameness in horses frequently associated with high expenses and failure to return to a previous level of performance. Conventional treatment regimens have various outcomes and mostly result in the formation of non-elastic scar tissue which plays a major role in the high incidence of recurrence. Scar tissue cannot be as functional as tendon and ligament tissue and the goal for an efficacious treatment is therefore the development of methods of regenerating the tissue and lessening the amount of scar tissue formation. The purpose of this study is to assess mesenchymal stem cell (MSC) therapy as a potential treatment for tendonitis and desmitis. The clinical use of stem cells is still in its early stages, and determination of the ideal dose to administer these cells is worth further investigation.

Stem Cell Study

Assessing a Stem Cell Therapy for Tendon and Ligament Injuries in Horses

Help us find a treatment for tendon and ligament injuries in horses using stem cells!

Tendon and ligament injuries are a common cause of lameness in horses frequently associated with high expenses and failure to return to a previous level of performance. Conventional treatment regimens have various outcomes and mostly result in the formation of non-elastic scar tissue which plays a major role in the high incidence of recurrence. Scar tissue cannot be as functional as tendon and ligament tissue and the goal for an efficacious treatment is therefore the development of methods of regenerating the tissue and lessening the amount of scar tissue formation. The purpose of this study is to assess stem cell therapy as a potential treatment for tendon and ligament injuries. The clinical use of stem cells is still in its early stages, and determination of the ideal dose to administer these cells is worth further investigation.

Stem Cell Study