UC Davis Veterinary Clinical Trials

Pituitary surgery for cats with pituitary tumors

Help us treat pituitary tumors in cats using surgery!

Cats with a brain tumor in their pituitary gland may produce too many hormones, causing a disease syndrome called feline hypersomatotropism (HS). It affects many organs including heart, kidneys, bone, and cartilage to name a few. Cats that suffer from hypersomatotropism will develop diabetes that is challenging to manage. One of the current treatments for feline HS is surgical removal of the pituitary gland. The purpose of this study is to find out the benefits of using BrainSight® neuronavigation system and Stortz® VITOM 3D endoscope to remove pituitary tumors in cats.

Device / Surgical Technique

Assessing and managing megaesophagus in dogs

Help us find better ways of treating dogs with megaesophagus!

Megaesophagus literally means large or giant esophagus and refers to a syndrome in which the muscles of the esophagus lose their tone and are no longer able to propel food and water from the mouth into the stomach. This disease is common in large-breed dogs in particular and can occur at any age. While some other diseases can cause megaesophagus, in over 50% of dogs no underlying or treatable cause is identified (known as idiopathic-acquired megaesophagus). As such, no targeted therapy can be implemented. Few advancements have been made in recommendations for disease management with current suggestions documented to be inadequate. We are assessing esophageal and lower esophageal sphincter (LES) function to optimize management of megaesophagus (ME) using novel medical therapies.

Understanding the genes behind Aspergillus spp. infections in German Shepherds, Rhodesian Ridgebacks and Hungarian Vizslas

Help us find out what genes cause Aspergillus spp. infections in German Shepherds, Rhodesian Ridgebacks and Vizslas!

Systemic fungal infections such as aspergillosis are rare in animals with a competent immune system; however, certain dog breeds (namely the German shepherd, Rhodesian ridgeback and Hungarian vizsla) are reported to have a higher risk of this uncommon disease. A genetic etiology is suspected to cause this over-representation. We propose to use a technique called genome-wide association analysis to evaluate the differences in the genetic material of affected dogs (dogs infected with Aspergillus spp.).

Genetic Study
Any, age None specified

Using a new device for the treatment of urinary incontinence in dogs

Help us look at a new surgical treatment for dogs who cannot control their urine!

Medical therapy using either phenylpropanolamine or synthetic estrogen, alone or in combination is currently considered first line medical therapy for urinary incontinence. While studies have shown that these medications are effective in some patients, both have potential side effects and life-long therapy is generally required. Various surgical treatment options have also been described for those dogs that do not respond to medical management or experience adverse effects from medications; however, these procedures are invasive, require considerable surgical skill to perform and are not always successful. Therefore, the purpose of this study is to test a new device, which uses heat to alter the structure of collagen in the wall of the urethra and thereby strengthen the wall and decrease leakage), to treat urinary incontinence in female dogs.

Device - Surgical Technique
Female, age None specified