UC Davis Veterinary Clinical Trials

Assessing a Stem Cell Treatment for Myasthenia Gravis (MG) in Dogs

Help us treat dogs with Myasthenia Gravis!

Myasthenia Gravis (MG) is a rare neuromuscular disease that is the result of an immune system attack on structures critical for nerve to muscle signaling. Clinical signs include generalized weakness and muscle weakness around the eyes, limbs or airways. There is no cure though some dogs will go into spontaneous remission. Novel stem cell therapies offer new hope for dogs with MG. For this clinical trial, we hope that adding stem cell treatment along with standard pharmaceutical treatment and care for MG will improve symptoms of the disease.

Stem Cell Study

Pituitary surgery for cats with pituitary tumors

Help us treat pituitary tumors in cats using surgery!

Cats with a brain tumor in their pituitary gland may produce too many hormones, causing a disease syndrome called feline hypersomatotropism (HS). It affects many organs including heart, kidneys, bone, and cartilage to name a few. Cats that suffer from hypersomatotropism will develop diabetes that is challenging to manage. One of the current treatments for feline HS is surgical removal of the pituitary gland. The purpose of this study is to find out the benefits of using BrainSight® neuronavigation system and Stortz® VITOM 3D endoscope to remove pituitary tumors in cats.

Device / Surgical Technique

Assessing a Stem Cell Therapy for Spina Bifida in English Bulldog Puppies

Help us find a treatment for spina bifida in dogs using stem cells!

Spina bifida (SB) occurs due to malformation of the spinal cord and/or vertebrae during pregnancy. It markedly affects the quality of a dog’s life. They have difficulties walking, or cannot walk at all, and are incontinent, predisposing them to repeated skin and urinary tract infections. As such, they do not make good pets for people and most often they are euthanized at a young age. The purpose of this study is to assess the efficacy of a novel stem cell therapy for spina bifida in English Bulldogs and compare the effects of reparative surgery alone to surgery plus a gel matrix and stem cell therapy for these dogs. Normal, healthy English Bulldogs will also be enrolled. Information collected from these dogs will be compared to the bulldogs with spina bifida to give us information on what the normal bulldog spine looks like and how the bulldog breed normally moves. With this information we can get a better sense of how well our treatment works in bulldogs who have spina bifida.

Other - Stem Cells
Any, age Less than 10 weeks of age

Assessing a Stem Cell Therapy for Inflammatory Brain Disease in Dogs

Help us find a treatment for inflammatory brain disease in dogs using stem cells!

Inflammatory central nervous system disease is a severe inflammatory disease in dogs, which can cause severe disease in the brain and spinal cord, causing dogs to become very sick. None of the current treatments are ideal, predictable and without possible complications. In recent years, stem cells have shown some promise as a potential treatment option for chronic inflammatory diseases, therefore, the purpose of this study is to assess the efficacy of stem cell therapy on dogs with inflammatory brain disease.

Other - Stem Cells
Any, age None specified