UC Davis Veterinary Clinical Trials

Novel Treatment for Nasal Tumors

Help us treat nasal tumors in dogs using a new kind of therapy!

Nasal tumors can cause severe nasal bleeding or discharge and difficulty breathing. These tumors often aggressively spread throughout the tissues of the nasal cavity and into the surrounding organs, including the eye and brain. Radiation therapy is the treatment of choice for nasal tumors in dogs; however, radiation therapy isn't often good for long-term control of the tumor. An another treatment option is transarterial embolization, or TAE, which involves the delivery of a mechanical “clot” to the main arteries supplying blood to the tissues of the nasal cavity with the goal of eliminating the blood supply of the tumor and decreasing tumor size. The purposes of this study are to 1) describe TAE in dogs with naturally-occurring nasal cancer, 2) evaluate the effect that nasal TAE has on the tumor, and 3) evaluate the effect that nasal TAE has on the values measured by positron emission tomography (PET) scanning.


Assessing a surgical treatment for dogs with hiatal hernia and/or gastroesophageal reflux

Help us learn more about this surgery to treat dogs with hiatal hernias and gastroesophageal reflux!

We believe that brachycephalic dogs have a tendency to develop hiatal herniation (HH) with greater frequency than non-brachycephalic dogs. Dogs with relative obstruction of the upper airways may generate a decreased pressure in their chest during inspiration (breathing in) that results in the upper part of the stomach being sucked into the chest (HH). This can lead to clinical signs including regurgitation, esophageal stricture formation and aspiration pneumonia if severe. We hypothesize that, if the upper airway obstruction in these dogs can be alleviated, improvement in their respiratory compromise might be seen as well as a reduction in the severity of their HH.

Device / Surgical Technique
Any, age None specified

Optimizing the identification of tumor spread to lymph nodes in dogs with oral tumors

Help us study a technique to find the spread of cancer better in dogs with oral tumors!

Successful treatment of many cancers depends on the extent of disease present at the time of diagnosis, and on accurate detection of that disease. Some oral cancers commonly spread from the mouth to nearby lymph nodes. Lymph node metastasis, if present, can influence the prognosis and treatment recommendations made for a patient. Currently, however, our standard veterinary staging protocol (aspiration cytology of the geographically nearest lymph node) misses a diagnosis of lymph node metastasis in a concerning number of patients. Because lymphatic pathways and lymph nodes of the head are very complicated and the closest lymph node is not necessarily the most likely to show disease, it is possible to miss disease because we do not know which is the best lymph node to evaluate. Lymph node mapping, a technique to visualize the lymphatic drainage of tumors, is increasingly used to improve cancer staging and treatment protocols in the treatment of cancer in people. Mapping allows identification of the “sentinel lymph node,” or lymph node that is most likely to demonstrate evidence of metastatic disease. This lymph node can then be aspirated or surgically removed with the primary tumor to be evaluated microscopically for spread of cancer. This trial is being performed to optimize a method of sentinel lymph node mapping that can be accessible to a greater number of veterinary practitioners in an effort to improve the accuracy of cancer diagnoses and treatment recommendations we make for our veterinary patients, improving their quality of life and length of time with us following diagnosis with this cancer.

Device / Surgical Technique
Any, age None specified

Surgical technique to place urethral stents in dogs with prostate, bladder and/or urethra tumors

Help us study a new technique to place urethral stents in dogs with prostate, bladder, and/or urethra tumors!

Cancer resulting in obstruction of the lower urinary tract of dogs is most commonly found in the prostate, urinary bladder and urethra (tube responsible for draining urine out of the body). Unfortunately, cancer of the lower urinary tract often results in complete blockage of the urethra, causing a patient to be unable to pass urine. The inability to urinate is a life-threatening emergency. The placement of urethral stents is generally performed with fluoroscopic-guidance (use of “real-time” x-rays). While fluoroscopy is useful for stent placement, there may be other techniques that could be considered. Traditionally, ultrasonographic assessment of tumor size and location has been performed by transabdominal ultrasound (where the ultrasound probe is placed on the abdominal wall to allow for visualization of organs within the abdomen), but this method can be inaccurate. The use of transrectal ultrasound (where an ultrasound probe is placed into the rectum) circumvents these previously discussed problems, and therefore, the purpose of this study is to evaluate this technique for efficacy.

Device / Surgical Technique
Any, age None specified