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UC Davis Veterinary Clinical Trials

Assessing a Stem Cell Treatment for Myasthenia Gravis (MG) in Dogs

Help us treat dogs with Myasthenia Gravis!

Myasthenia Gravis (MG) is a rare neuromuscular disease that is the result of an immune system attack on structures critical for nerve to muscle signaling. Clinical signs include generalized weakness and muscle weakness around the eyes, limbs or airways. There is no cure though some dogs will go into spontaneous remission. Novel stem cell therapies offer new hope for dogs with MG. For this clinical trial, we hope that adding stem cell treatment along with standard pharmaceutical treatment and care for MG will improve symptoms of the disease.

Stem Cell Study
Any

Pituitary surgery for cats with pituitary tumors

Help us treat pituitary tumors in cats using surgery!

Cats with a brain tumor in their pituitary gland may produce too many hormones, causing a disease syndrome called feline hypersomatotropism (HS). It affects many organs including heart, kidneys, bone, and cartilage to name a few. Cats that suffer from hypersomatotropism will develop diabetes that is challenging to manage. One of the current treatments for feline HS is surgical removal of the pituitary gland. The purpose of this study is to find out the benefits of using BrainSight® neuronavigation system and Stortz® VITOM 3D endoscope to remove pituitary tumors in cats.

Device / Surgical Technique

Finding the genes causing epilepsy in dogs

Help us find out what genes cause epilepsy in dogs!

Epilepsy is a neurological disorder that causes abnormal bursts of electrical activity in the brain (lasting from seconds to minutes). Seizures are characterized by jerking of the limbs, anxiety, salivation, vocalizing, and loss of bodily functions (urination/defecation). Epilepsy can be caused by metabolic disorders, infectious diseases, brain injury, toxins, or brain tumors. A genetic seizure condition in dogs can occur called idiopathic (of unknown cause) or inherited epilepsy. Since a dog with idiopathic epilepsy shows no recognizable abnormalities, it is assumed to be an inherited condition in most breeds and demonstrated to be heritable in some breeds. Treatment of seizures is usually two-fold which includes treatment of the underlying problem (infection, tumor, injury) and reducing or eliminating the seizure episodes with anticonvulsant medication. The overall purpose of this study is three-fold: * To evaluate the mode of inheritance of canine diseases; * To identify the genes responsible for disease expression; and, * To join the tools of statistics with the promise of molecular genetics.

Genetic Study

Understanding the genetics causing intervertebral disc disease in Poodles

Help us find out what genes cause intervertebral disc disease in Poodles!

Some breeds of dogs are at an increased risk of type 1 Intervertebral Disc Disease (IVDD), which is described by herniation of the calcified nucleus pulposus into the vertebral column. Type 1 IVDD causes severe pain and neurological dysfunction and requires prompt corrective surgery. While a genetic cause for chondrodystrophy (CDDY) has recently been identified, not all chondrodystrophic dogs suffer an intervertebral herniation event in their lifetime, suggesting that there may be additional factors that increase risk for type 1 IVDD. While CDDY is fixed in some breeds, such as Dachshunds and Beagles, CDDY is variable within poodles, making them ideal for studying IVDD. Studying IVDD in poodles could allow us to determine the relative risk for IVDD associated with 1 or 2 copies of CDDY, as well as determine any other factors which could contribute to increased risk of IVDD within the breed.

Genetic Study

Assessing a Stem Cell Therapy for Spina Bifida in English Bulldog Puppies

Help us find a treatment for spina bifida in dogs using stem cells!

Spina bifida (SB) occurs due to malformation of the spinal cord and/or vertebrae during pregnancy. It markedly affects the quality of a dog’s life. They have difficulties walking, or cannot walk at all, and are incontinent, predisposing them to repeated skin and urinary tract infections. As such, they do not make good pets for people and most often they are euthanized at a young age. The purpose of this study is to assess the efficacy of a novel stem cell therapy for spina bifida in English Bulldogs and compare the effects of reparative surgery alone to surgery plus a gel matrix and stem cell therapy for these dogs. Normal, healthy English Bulldogs will also be enrolled. Information collected from these dogs will be compared to the bulldogs with spina bifida to give us information on what the normal bulldog spine looks like and how the bulldog breed normally moves. With this information we can get a better sense of how well our treatment works in bulldogs who have spina bifida.

Other - Stem Cells
Any, age Less than 10 weeks of age