UC Davis Veterinary Clinical Trials

Pituitary surgery for cats with pituitary tumors

Help us treat pituitary tumors in cats using surgery!

Cats with a brain tumor in their pituitary gland may produce too many hormones, causing a disease syndrome called feline hypersomatotropism (HS). It affects many organs including heart, kidneys, bone, and cartilage to name a few. Cats that suffer from hypersomatotropism will develop diabetes that is challenging to manage. One of the current treatments for feline HS is surgical removal of the pituitary gland. The purpose of this study is to find out the benefits of using BrainSight® neuronavigation system and Stortz® VITOM 3D endoscope to remove pituitary tumors in cats.

Device / Surgical Technique

Finding the genes causing symmetrical lupoid onychodystrophy in Bearded collies

Help us find out what genes cause symmetrical lupoid onychodystrophy in Bearded collies!

Canine Genetic Disease Project - Symmetrical Lupoid Onychodystrophy Purpose: Symmetrical Lupoid Onychodystrophy (SLO) is a chronic autoimmune disorder that causes a loss of toenails in many breeds, including Bearded Collies. The age of onset is typically between 3-8 years of age affecting 1-2 nails and eventually progressing to all nails. Scientists believe that heredity may be one of the contributing causes of this disease. The overall purpose of this study is three-fold: * To evaluate the mode of inheritance of canine diseases; * To identify the genes responsible for disease expression; and, * To join the tools of statistics with the promise of molecular genetics.

Genetic Study

Finding the genes causing Addison's disease in dogs

Help us find out what genes cause Addison's Disease in dogs!

Addison’s Disease or Hypoadrenocorticism is a deficiency in the secretion of both glucocorticoids and mineralcorticoids from the adrenal cortex. The cause is unknown; however, there appears to be an immune mediated destruction of the adrenal gland in most cases. Symptoms include inappetance, vomiting, lethargy and weakness. An ACTH stimulation test to evaluate the ability of the adrenal gland to secrete cortisol can be used for diagnosis. Affected dogs show low cortisol concentrations, and no increase in cortisol following the ACTH test. Treatment for this disease includes fluid therapy, replacement of glucocorticoids and mineralcorticoids, and hormone therapy. The overall purpose of this study is three-fold: * To evaluate the mode of inheritance of canine diseases; * To identify the genes responsible for disease expression; and, * To join the tools of statistics with the promise of molecular genetics.

Genetic Study