UC Davis Veterinary Clinical Trials

Circulating DNA in cats with hypertrophic cardiomyopathy and cardiogenic arterial thromboembolism

Help us look for a screening test to prevent clot formation in cats

Hypertrophic cardiomyopathy (HCM) is the most common heart disease in cats. About 20% of cats will develop clinical signs due to HCM. Of these complications, the most devastating is cardiogenic arterial thromboembolism (clot formation), otherwise known as, “saddle thrombus”, which is one of the most distressing emergencies for cat owners. This disease is complicated by the fact that most cats that develop saddle thrombus appear healthy and do not have heart murmurs. Veterinarians currently have limited abilities to test and treat cats at the greatest risk of forming saddle thrombus. For this reason, we hope to look for protein markers and free circulating DNA in the blood of cats with HCM and saddle thrombus. Free circulating DNA has been shown in humans, mice and dogs to promote clot formation and can be used as a treatment target. We, therefore, hope to further understand these findings by seeing if free circulating DNA in cats contribute to saddle thrombus in cats with HCM. This information will enable us to establish a screening test that will guide clinicians in identifying cats at risk of clot formation.

Observational
Any, age > 1 year old

Finding the genes causing symmetrical lupoid onychodystrophy in Bearded collies

Help us find out what genes cause symmetrical lupoid onychodystrophy in Bearded collies!

Canine Genetic Disease Project - Symmetrical Lupoid Onychodystrophy Purpose: Symmetrical Lupoid Onychodystrophy (SLO) is a chronic autoimmune disorder that causes a loss of toenails in many breeds, including Bearded Collies. The age of onset is typically between 3-8 years of age affecting 1-2 nails and eventually progressing to all nails. Scientists believe that heredity may be one of the contributing causes of this disease. The overall purpose of this study is three-fold: * To evaluate the mode of inheritance of canine diseases; * To identify the genes responsible for disease expression; and, * To join the tools of statistics with the promise of molecular genetics.

Genetic Study

Finding the genes causing epilepsy in dogs

Help us find out what genes cause epilepsy in dogs!

Epilepsy is a neurological disorder that causes abnormal bursts of electrical activity in the brain (lasting from seconds to minutes). Seizures are characterized by jerking of the limbs, anxiety, salivation, vocalizing, and loss of bodily functions (urination/defecation). Epilepsy can be caused by metabolic disorders, infectious diseases, brain injury, toxins, or brain tumors. A genetic seizure condition in dogs can occur called idiopathic (of unknown cause) or inherited epilepsy. Since a dog with idiopathic epilepsy shows no recognizable abnormalities, it is assumed to be an inherited condition in most breeds and demonstrated to be heritable in some breeds. Treatment of seizures is usually two-fold which includes treatment of the underlying problem (infection, tumor, injury) and reducing or eliminating the seizure episodes with anticonvulsant medication. The overall purpose of this study is three-fold: * To evaluate the mode of inheritance of canine diseases; * To identify the genes responsible for disease expression; and, * To join the tools of statistics with the promise of molecular genetics.

Genetic Study

Finding the genes causing Addison's disease in dogs

Help us find out what genes cause Addison's Disease in dogs!

Addison’s Disease or Hypoadrenocorticism is a deficiency in the secretion of both glucocorticoids and mineralcorticoids from the adrenal cortex. The cause is unknown; however, there appears to be an immune mediated destruction of the adrenal gland in most cases. Symptoms include inappetance, vomiting, lethargy and weakness. An ACTH stimulation test to evaluate the ability of the adrenal gland to secrete cortisol can be used for diagnosis. Affected dogs show low cortisol concentrations, and no increase in cortisol following the ACTH test. Treatment for this disease includes fluid therapy, replacement of glucocorticoids and mineralcorticoids, and hormone therapy. The overall purpose of this study is three-fold: * To evaluate the mode of inheritance of canine diseases; * To identify the genes responsible for disease expression; and, * To join the tools of statistics with the promise of molecular genetics.

Genetic Study

Understanding the genes behind Aspergillus spp. infections in German Shepherds, Rhodesian Ridgebacks and Hungarian Vizslas

Help us find out what genes cause Aspergillus spp. infections in German Shepherds, Rhodesian Ridgebacks and Vizslas!

Systemic fungal infections such as aspergillosis are rare in animals with a competent immune system; however, certain dog breeds (namely the German shepherd, Rhodesian ridgeback and Hungarian vizsla) are reported to have a higher risk of this uncommon disease. A genetic etiology is suspected to cause this over-representation. We propose to use a technique called genome-wide association analysis to evaluate the differences in the genetic material of affected dogs (dogs infected with Aspergillus spp.).

Genetic Study
Any, age None specified
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