UC Davis Veterinary Clinical Trials

Understanding the genetics causing subvalvular aortic stenosis in Bullmastiffs

Help us find out what genes cause subvalvular aortic stenosis in Bullmastiffs!

Subvalvular aortic stenosis (SAS) is the second most common heart defect diagnosed in dogs, and the Bullmastiff breed is over-represented in incidence of SAS. Moderate and severely affected cases are at risk for developing severe cardiac complications, and have an average lifespan of 19 months. Furthermore, there is no surgical treatment available that results in an increased life expectancy for affected cases. The aim of this study is to identify genes/variants associated with SAS in Bullmastiffs that can be used to develop a genetic test.

Other - Genetic Study
Any, age None specified

What are the Effects of Pimobendan on Hypertrophic Cardiomyopathy in Cats?

Help us Look at a Treatment for Hypertrophic Cardiomyopathy in Cats!

Hypertrophic cardiomyopathy (HCM) is the most common heart disease in cats and we do not have a good understanding of how to best treat this devastating disease. One drug, pimobendan, has been shown to have significant clinical benefits in cats with HCM, but more studies are needed to evaluate exactly how this drug affects heart function. The purpose of this clinical trial is to evaluate the effects of pimobendan on heart function in cats affected with HCM, which will help us make with better treatment recommendations for cats with this disease.